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Histamine Receptor抑制剂
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Amitriptyline 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。 Cancers (Basel), 2019, 11(12) S4240: Doxylamine Succinate
The histamine receptors are a type of G protein-coupled receptors which bind histamine as their primary endogenous ligand. Histamine is a well-established mediator involved in a variety of physiological and pathophysiological mechanisms and exerts its effect through activation of four histamine receptors (H1-H₄).
MCE (MedChemExpress) 提供 Histamine Receptor抑制剂、激动剂、拮抗剂、激活剂、调节剂、基因，生物活性验证，全球文献广泛引用，专注于信号通路和疾病研究领域，致力于为生命科学研究提供高质量的试剂类产品和服务。
Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarinic receptor )、组胺受体 (histamine receptor )、5-羟色胺受体 (5-HT receptor)。Amitriptyline hydrochloride 是一种具有强神经营养活性的 TrkA 和 TrkA 受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。
Cimetidine (CAS 51481-61-9) acts as a histamine H2 receptor inhibitor, affecting gastric acid regulation by competitively binding to H2 receptors and modulating their activity. Ranitidine hydrochloride: 66357-59-3: sc-204874: 1 g: $32.00 (0) Ranitidine hydrochloride is a histamine H2-receptor antagonist. Famotidine:
Effect of histamine receptor antagonists on histamine-induced inhibition of lactoferrin release. Human PMNs (1×10 6) were preincubated for 5 min, without or with the indicated concentrations of the H 4 receptor antagonists JNJ 7777120 (A), or JNJ 28307474 (B). Thereafter, histamine (1 μM) was added for 5 min. PMNs were then incubated on ...
The histamine receptor H3 regulates NSCLC cell proliferation and apoptosis. a,b Cell viability was measured by CCK-8 assay in H1975, H460, A549, and BEAS-2B cells treated with the Hrh3 antagonist CPX or Hrh3 agonist RAMH for 48 h.
抗组胺药（antihistamine）经常用于治疗过敏。在一项新的临床前研究中，来自美国德克萨斯大学MD安德森癌症中心的研究人员发现用抗组胺药治疗与免疫检查点抑制剂的反应改善有关。他们发现组胺受体H1（HRH1）在肿瘤…
S 38093是一种组胺H3受体（histamine H3 receptors）的反向激动剂，对大鼠，小鼠和人H3受体显示出中等亲和力，Ki值分别为8.8，1.44和1.2 μM。 M9172 Emedastine Difumarate: Emedastine Difumarate is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity.
组胺（Histamine）是一种内源性生物胺，通过作用于G蛋白偶联受体（Gprotein-coupledreceptor，GPCR）家族中的四种不同的组胺受体（H1R、H2R、H3R、H4R）介导多种生理和病理过程。组胺H1受体（H1R）和组胺H2受体（H2R）分别与过敏反应和胃酸分泌相关，而组胺H4受体（H4R）主要参与机体的免疫反应。