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ANGPTL3 is a protein encoded by the ANGPTL3 gene that regulates lipid metabolism and angiogenesis. It is a member of the angiopoietin-like family and binds to integrins and lipases.
ANGPTL3 is a protein that regulates lipid metabolism and is associated with lower risk of coronary artery disease. Learn about the latest trials of evinacumab and vupanorsen, two therapies that inhibit ANGPTL3 and reduce LDL-C and triglycerides.
Angiopoietin-like 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases and hepatic uptake of triglyceride-rich lipoprotein remnants. ANGPTL3 loss-of-function carriers have lower levels of trigl...
Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein that mainly expresses in the liver, and is regulated by numerous post-translational modifications, including multiple cleavage and glycosylation. Accumulating evidences have revealed that ANGPTL3 plays a critical rol …
ANGPTL3 is a protein coding gene that regulates lipid and glucose metabolism, angiogenesis, and podocyte function. It is involved in several diseases, such as familial hypobetalipoproteinemia type 2 and developmental and epileptic encephalopathy 23.
Angiopoietin-like proteins (ANGPTLs) have emerged as an important regulator of lipid and glucose metabolism as well as insulin sensitivity. ANGPTL3 plays a key role in regulating circulating triglycerides (TG) and cholesterol levels through ...
Genetic and preliminary intervention studies published in two papers in NEJM indicate that angiopoietin-related protein 3 (ANGPTL3) is a promising therapeutic target in patients with dyslipidaemia ...
Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3, a gene located in an intron of DOCK7, results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG). We identified ...
Angiopoietin-like 3 (ANGPTL3), a 70 kDa glycoprotein principally expressed and secreted by hepatocytes, is a member of the angiopoietin-like protein family exclusively synthesized in the liver.
Recently, we have begun developing a peptide-based anti-ANGPTL3 vaccine and confirmed in a preclinical FH mouse model that it significantly decreases LDL-C and TG levels, reduces atherosclerotic lesions and maintains long-term efficacy without adverse effects.