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1277 12842 Ensembl ENSG00000108821 ENSMUSG00000001506 UniProt P02452 P11087 RefSeq (mRNA) NM_000088 NM_007742 RefSeq (protein) NP_000079 NP_031768 Location (UCSC) Chr 17: 50.18 - 50.2 Mb Chr 11: 94.83 - 94.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene ...
The COL1A1 gene provides instructions for making part of a protein called type I collagen, which strengthens and supports many tissues in the body. Mutations in this gene can cause various disorders, such as Caffey disease, Ehlers-Danlos syndrome, osteogenesis imperfecta, and dermatofibrosarcoma protuberans.
COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Enhanced binding of GP1BA variant to VWF multimer:collagen.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth ...
Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in the body.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical ...
Protein Gene Interaction Pubs; Envelope surface glycoprotein gp120: env: HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells
Sundar Raj et al. (1977) used the methods of cell hybridization and microcell hybridization to assign a collagen I gene to chromosome 17. Solomon and Sykes (1979) concluded, incorrectly as it turned out, that both the alpha-1 and the alpha-2 genes of collagen I are on chromosome 7. Solomon and Sykes (1979) also presented evidence that the alpha-1 chains of collagen III are also coded by ...
Red COLA1 cells allow for enhanced sensitivity and dynamic response compared to endogenous type I collagen. In culture, type I collagen expression in fibroblasts can be detected with antibodies ...
Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone matrix. However, the precise cellular origin and functional ...
Red-COLA1 is a human fibroblast cell line that expresses a fluorescent reporter downstream of the COL1A1 promoter. It can be used to study the regulation of type I collagen expression by various factors, such as TGF-β1, in wound healing, fibrosis and aging.