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gpd2
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The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene ...
Fig. 1: Enzymatic reactions mediated by GPD1 and GPD2. The GPD1 gene is 7306 bp in length and is located on human chr12q13.12. It includes eight exons and seven introns and encodes a protein ...
GPD2, a component of the glycerol phosphate shuttle, boosts glucose oxidation to fuel the production of acetyl coenzyme A, acetylation of histones and induction of genes encoding inflammatory mediators. While acute exposure to LPS drives macrophage activation, prolonged exposure to LPS triggers tolerance to LPS, where macrophages induce ...
Mitochondrial glycerophosphate dehydrogenase (EC 1.1.99.5), or GPD2, is located on the outer surface of the inner mitochondrial membrane and catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD.Together with a cytosolic NAD-linked GPD (GPD1; 138420), GPD2 forms the glycerol phosphate ...
GPD2 is a protein coding gene that encodes a mitochondrial enzyme involved in glycerol phosphate shuttle and glucose sensing. Learn about its aliases, disorders, pathways, products, expression, localization, and more.
GPD2 is located on the outer face of the mitochondrial inner membrane, where it oxidizes G3P to dihydroxyacetone phosphate (DHAP) and uses the electrons generated to reduce the CoQ pool 3 (Fig. 1 ...
Clinical resource with information about GPD2, A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis., Genome-wide association of lipid-lowering response to statins in combined study populations., Type 2 diabetes mellitus, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus ...
GPD2 1 Systematic Name YOL059W SGD ID SGD:S000005420 Aliases GPD3 Feature Type ORF , Verified Description NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate ...
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene ...
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD +-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked glycerol 3-phosphate dehydrogenase 2 (GPD2).These two enzymes work together to act as an NADH shuttle for mitochondrial bioenergetics and function as an important bridge between glucose and lipid metabolism.