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Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by T helper 17 cells. Learn about the structure, function, and role of IL-17 in various immune responses and diseases.
Interleukin-17 (IL-17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host-defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad ...
The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago.
IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL ...
Abstract. The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th anniversary of its discovery. While less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease.
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th anniversary of its discovery. Although less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease.
IL-17A, often referred to as IL-17, was originally discovered at transcriptional level by Rouvier et al. in 1993 from a rodent T-cell hybridoma, derived from the fusion of a mouse cytotoxic T cell clone and a rat T cell lymphoma. [5] Human and mouse IL-17A were cloned a few years later by Yao [7] and Kennedy. [8] Lymphocytes including CD4+, CD8+, gamma-delta T (γδ-T), invariant NKT and ...
IL-17 (also known as IL-17A) is most homologous to IL-17F (~60%), and the genes encoding them are proximally located on chromosome 6. IL-17 and IL-17F exist as homodimers [], and it was recently shown that IL-17A and IL-17F, which are both produced by Th17 cells (see xx below) also form a heterodimeric cytokine termed IL-17A/F [10, 11].IL-17F is the only member of the subfamily whose 3 ...
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer.
The IL-17 receptor is expressed ubiquitously, therefore most cells can potentially respond to this cytokine . Furthermore, although IL-17 alone is a weak inducer of target genes, it has been shown to synergize with IL-1β, IL-22, IFN-γ, TNF-α and other cytokines in vivo .