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MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. [3] MiR-155 plays a role in various physiological and pathological processes. [4][5][6][7][8][9] Exogenous molecular control in vivo of miR-155 expression may inhibit malignant growth, [10][11] viral infections, [12] and enhance the progression of cardiovascular diseases. [13]
We will also provide examples of miR-155-regulated networks in coordination with other noncoding RNAs, including long noncoding RNAs as well as coding mRNAs acting as competing endogenous RNAs.
MIR155 is a noncoding microRNA transcript of the B-cell integration cluster gene, implicated in the regulation of various cellular processes, including immune response and oncogenesis [PMC7912829].
4.1 miR-155 MiR-155, located on chromosome 21, is an oncogenic miRNA [137]. As a multifunctional miRNA, miR-155 plays a crucial role in a variety of physiological and pathological processes of cells. Increasing evidence suggests that miR-155 is highly expressed in many different types of tumors [138-140].
Gene target information for MIR155 - microRNA 155 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
2. MicroRNA-155 (MiR-155) miR-155 transcribed from the B cell integration cluster was located on chromosome 21 and acted as a promoter of both inflammation and upregulation of salient oncogenic microRNAs (oncomiRs) in many human cancers [12]. miR-155 was an important biomarker for understanding the molecular mechanisms and etiology of various diseases [13, 14]. miR-155 was mainly expressed in ...
MiR-155 degrades c-Maf, known for its anti-inflammatory activity, thus promoting pro-inflammatory processes of microglia. The correlation between p53, miR-155 and c-Maf was analyzed in adult murine microglia after induced neuroinflammation through the middle cerebral artery occlusion (MCAO) for 15 min.
MiR-155 is a pro-inflammatory mediator of the CNS and plays an important regulatory role. The purpose of this review is to summarize how miR-155 is regulated and the pathological consequences of its deregulation during neuroinflammatory disorders, including multiple sclerosis, Alzheimer's disease and other neuroinflammatory disorders.
An inhibitor of miR-155 called cobomarsen [3] has shown promise in the treatment of several cancers. Although miR-155-based therapies have potential, less developed nations may find it difficult to obtain these cutting-edge therapies. Inequalities in healthcare access may result from the expense of creating and deploying miRNA-based treatments.
The forming process of microRNA. 2. MicroRNA-155 (MiR-155) miR-155 transcribed from the B cell integration cluster was located on chromosome 21 and acted as a promoter of both inflammation and upregulation of salient oncogenic microRNAs (oncomiRs) in many human cancers [12]. miR-155 was an important biomarker for understanding the molecular mechanisms and etiology of various diseases [13, 14 ...