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Post-cardiac arrest syndrome (PCAS) is an inflammatory state that can occur after resuscitation from a cardiac arrest. It affects multiple organs and depends on the length of ischemic period and the quality of CPR.
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The first large multicenter report on patients treated for cardiac arrest was published in 1953. 4 The in-hospital mortality rate for the 672 adults and children whose "heart beat was restarted" was 50%. More than a half-century later, the location, cause, and treatment of cardiac arrest have changed dramatically, but the overall prognosis after ROSC has not improved.
The University of Pittsburgh Post-Cardiac Arrest Service (PCAS) is a multidisciplinary group of clinicians and researchers from the Departments of Emergency Medicine, Critical Care Medicine, Neurology, Cardiology, Radiology, and Physical Medicine & Rehabilitation dedicated to improving care and outcomes for patients who survive cardiac arrest. . Founded in 2007 at UPMC Presbyterian, PCAS ...
Plasmid pCas from Dr. Sheng Yang's lab contains the insert cas9 and is published in Appl Environ Microbiol. 2015 Jan 30. pii: AEM.04023-14. This plasmid is available through Addgene. Image: Illustrated plasmid map in PNG format. GenBank File: Plasmid sequence and annotations. Use text editor or plasmid mapping software to view sequence. ...
Post-cardiac arrest syndrome (PCAS) is a multicomponent entity affecting many who survive an initial period of resuscitation following cardiac arrest. This focussed review explores some of the strategies for mitigating the effects of PCAS following the return of spontaneous circulation. We consider …
In 2008, PCAS was defined for the international resuscitation community in an International Liaison Committee on Resuscitation scientific statement. 4 This statement addressed chiefly adult PCAC, highlighting the pathophysiology and the need for continued multisystem support after ROSC. 4 The statement described what are now accepted as 4 key ...
This article comprehensively examines the epidemiology, pathophysiology, and therapeutic strategies for post-arrest lung injury (PALI), a common complication of post-cardiac arrest syndrome (PCAS). PALI is a multifactorial condition that involves trauma, pulmonary ischemia-reperfusion injury, aspiration, and inflammation, and requires lung-protective ventilation and mitochondrial-targeted therapies.
PCAS is a pathological condition after ROSC following cardiac arrest. This chapter reviews the severity, brain injury, prognosis, treatment, and future directions of PCAS.
Our understanding of the immune system contributions to the PCAS has expanded, with animal models detailing biologically plausible mechanisms of secondary injury, the protective effects of available immunomodulatory drugs, and how immune dysregulation underlies infection susceptibility after arrest. In this narrative review, we discuss the ...