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HAVCR2, also known as TIM-3, is a protein that regulates the immune response and is involved in autoimmunity and cancer. Learn about its discovery, classification, structure, function, and ligands.
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), first discovered in 2002 (ref. 1), is a member of the TIM family of immunoregulatory proteins.These are characterized by a ...
Mouse genetic studies and single-cell transcriptome analysis demonstrate that TIM-3 on dendritic cells has a key role in regulating antitumour immunity via inflammasome activation and is a ...
This review article discusses the distinct functions of LAG-3, TIM-3, and TIGIT, which are co-inhibitory receptors that regulate T cell and other immune responses. It covers their ligands, signaling, roles in disease, and clinical applications.
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4 + and CD8 + T cells. Initial data indicated that TIM3 functioned as a 'co-inhibitory' or 'checkpoint' receptor, but due to the lack of a definable inhibitory signalling motif, it was also suggested that TIM3 might act ...
T cell immunoglobulin and mucin domain 3 (TIM-3) was originally found to be expressed on the surface of Th1 cells, acting as a negative regulator and binding to the ligand galectin-9 to mediate Th1 cell the apoptosis. Recent studies have shown that TIM-3 is also expressed on other immune cells, such …
Tim-3 serves as a major regulator of immunity in the lymphoid (A) and myeloid (B) compartments. In DCs (dendritic cells), HMGB1 plays a critical role in the transport of nucleic acids into enodosomal vesicles, which is a key step for DCs to sense tumor-derived stress factors or pathogen-associated molecular patterns (PAMPs) and to generate protective immune responses to tumors.
Described for the first time in 2002, TIM-3 was found as a molecule specifically expressed on terminally differentiated IFN-γ-secreting CD4 + T helper 1 (T H 1) and CD8 + T cytotoxic 1 (Tc1) cells (), with studies initially describing a role for TIM-3 in restraining T H 1-driven autoimmunity. Since then, TIM-3 has emerged as an important negative regulator of effector T cell responses in ...
T cell inhibitory co-receptors play a crucial role in maintaining the balance between physiologic immune responses and maladaptive ones. T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a unique inhibitory co-receptor in that its expression is chiefly restricted to interferon (IFN)γ-producing CD4 + and CD8 + T cells. Early reports firmly established its importance in maintaining ...
TIM3 is activated by galectin-9, is expressed by T H 1 cells and suppresses aggressive T H 1-cell responses. In this study, Anderson et al. showed that TIM3 is also expressed by naive dendritic ...