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There is an urgent need for highly effective therapeutic agents to interrupt the continued spread of SARS-CoV-2. As a pivotal protease in the replication process of coronaviruses, the 3CLpro protein is considered as a potential target of drug development to stop the spread and infection of the virus …
Comment: WU-04 is a noncovalent (reversible) inhibitor of the SARS-CoV-2 main protease (Mpro; 3CLpro) []. In vitro nhibition of SARS-CoV and MERS-CoV main proteases is also demonstrated.
The 3C-like protease (3CLpro) is an essential enzyme for the replication of SARS-CoV-2 and other coronaviruses and thus is a target for coronavirus drug discovery. Nearly all inhibitors of coronavirus 3CLpro reported so far are covalent inhibitors. Here, we report the development of specific, noncovalent inhibitors of 3CLpro. The most potent one, WU-04, effectively blocks SARS-CoV-2 ...
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The 3C-like protease (3CLpro) is an essential enzyme for the replication of SARS-CoV-2 and other coronaviruses and thus is a target for coronavirus drug discovery. Nearly all inhibitors of coronavirus 3CLpro reported so far are covalent inhibitors. Here, we report the development of specific, noncov …
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Yukon Gear & Axle Spin Free Locking Hub Conversion Kits for 2000-2008 RAM 2500, RAM 3500 - YA WU-04 YGA-21728. 4.25 out of 5 stars. Part Number: YGA-21728 Estimated Ship Date: Jun 12, 2025
a The crystal structure of the WT SARS-CoV-2 3CLpro in complex with WU-04 (PDB code: 7EN8). Two double mutations M49K/M165V and M49K/S301P of SARS-CoV-2 3CLpro were identified as WU-04-resistant ...