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The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta ...
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Complete information for IL3RA gene (Protein Coding), Interleukin 3 Receptor Subunit Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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The splicing variants of IL-3RA, thus demonstrate how alternate splicing can promote significant phenotypic changes and differential signaling by alteration of ligand receptor interactions. Interleukin-5 receptor (IL-5R) is a 420 amino acid heterodimeric protein involved in eosinophil production (Fig. 3 G).
GeneRIFs: Gene References Into Functions EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha. High IL3RA expression is associated with breast cancer. expression of the interleukin 3 receptor alpha (Il3ra also ...
Gene target information for IL3RA - interleukin 3 receptor subunit alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
IL3RA interleukin 3 receptor subunit alpha Gene ID: 3563, updated on 4-Jan-2025 Gene type: protein coding Also known as: IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; IL-3R-alpha See all available tests in GTR for this gene Go to complete Gene record for IL3RA Go to Variation Viewer for IL3RA variants Summary The protein encoded by this gene is an interleukin 3 specific subunit of a ...
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The gene encoding interleukin-3 receptor is located in the pseudoautosomal region (PAR) at the end of the short arm of the X and Y chromosomes. The IL-3R alpha chain gene contains twelve exons and eleven introns that span an area of approximately 40 Kb. It is positioned near (190 Kbp) to the gene encoding for GM-CSFR alpha chain. Both the IL-3R alpha and GM-CSFR alpha genes display a similar ...