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Buy Macitentan, CAS number: 441798-33-0, online for pharmaceutical analytical testing. The highest quality reference standards for reliable results.
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC 50 s = 0.5 and 391 nM in a radioligand binding assay using recombinant ET A and ET B, respectively). 1 Macitentan inhibits intracellular Ca 2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC 50 = 0.9 nM), contractions of isolated rat aortic rings (pA 2 ...
Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5- (4-bromophenyl)-6- {2- [ (5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an ...
Buy Macitentan (CAS 441798-33-0), a dual endothelin receptor antagonist, from Santa Cruz. Molecular Formula: C19H20Br2N6O4S, Molecular Weight: 588.27
macitentan (CAS 441798-33-0) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices ...
Macitentan is an orally active, non-peptide dual endothelin (ET)(A) and ET(B) receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Macitentan (ACT-064992; actelion-1) is an orally active, potent endothelin (ET) receptor antagonist that blocks ET-1-induced cellular calicum response (IC50 in nM = 0.9/HPASMC, 0.8/RASMC, 1.84/m3T3), as well as ET-1-induced contractions of rat aortic rings (ETA) and S6c-induced rat tracheal rings (ETB) ex vivo (pA2 = 7.6 and 5.9, respectively). Macitentan displays therapeutic efficacy in rat ...
Buy high-quality Macitentan from SynZeal. Macitentan Reference Standard is supplied with COA and analytical data. CAS No. 441798-33-0, Synonyms: , Chemical name: N- [5- (4-Bromophenyl)-6- [2- [ (5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-Sulfamide .
Product number: C4883 CAS number: 441798-33- Molecular formula: C 19 H 20 Br 2 N 6 O 4 S Molecular weight: 588,27 g.mol-1 Min. purity: 98,00 % Synonyms: ACT 064992 Solubility: refer to COA
Macitentan is a new dual ETA/ETB endothelin (ET) receptor antagonist, with mean IC50 values of 0.5 ± 0.2 nM (n= 17) to inhibit the binding of 125I-ET-1 to recombinant ETA receptors, and of 391±182 nM (n= 17) for ETB receptors in Chinese hamster ovary cells [1]. ETA and ETB are ET receptors, both of them mediate the detrimental actions of ET-1, and dual blockade of them may be necessary [1 ...