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HATU
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HATU is a white crystalline solid that activates carboxylic acids to form active esters for amide bond formation. It is used with a base and a polar aprotic solvent, and has a high coupling efficiency and a moderate skin sensitization risk.
O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | C10H15F6N6OP | CID 6409673 - structure, chemical names, physical and chemical properties ...
Aldrich-445460; HATU 0.97; CAS No.: 148893-10-1; Synonyms: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; N ...
hatu的缩合反应机理 hatu是羧酸酰胺化反应中最常用的缩合剂之一，相对于其他类似缩合剂（如，hbtu）反应速度更快，不易消旋。 利用hatu进行酰胺化反应，条件温和，产率高，很多大位阻的缩合剂也能反应，广泛应用于合成各种医药中间体。
HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis.It was introduced in 1978 and shows resistance against racemization. [3] [4] It is used because of its mild activating properties.[5]HBTU is prepared by reaction of HOBt with TCFH under basic conditions [6] and was assigned to a uronium type structure, presumably by analogy ...
Example 3. To a solution of the acid (200 mg, 0.7 mmol) in DMF (3.0 mL) at 0 C was added HATU (550 mg, 1.4 mmol) and DIEA (280 mg, 2.1 mmol), followed by the addition of the amine (173 mg, 0.8 mmol). The resulting mixture was stirred at RT for 1 h, after which time the reaction mixture was diluted with H2O and extracted with EtOAc.The org layer was dried and concentrated in vacuo.
Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium (HATU) is a reagent used in peptide coupling. You can purchase this chemical in three catalog sizes: 25g, 100g or 250g, but also good for bulk quantity. HATU is a key chemical used to form a coupling reaction, creating a formation as part of peptide synthesis. See prices below.
HATU - chemical structure, common uses, and safety. Structure: CAS Number: 148893-10-1 Molecular Weight: 380.23 g/mol Appearance: White crystalline solid Melting Point: 183-185 C
Stability: HATU is relatively stable but should be stor in a cool, dry place away from light and moisture to maintain its reactivity. Applications: Peptide Synthesis: HATU is widely used in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis due to its high efficiency and low racemization rates. It provides faster reaction ...
HATU is a highly active coupling reagent that often produces superior results in difficult couplings compared to HBTU. Coupling reactions utilizing HATU generally are faster, produce higher yields and less racemization. Coupling Protocol. SDS. Bulk Order Add to cart. Related products.