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KRT17 is a gene that encodes keratin 17, a type I intermediate filament chain involved in skin appendage formation and maintenance. Learn about its aliases, disorders, pathways, products, expression, localization, and more.
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene. [5] [6] [7] [8]Keratin 17 is a type I cytokeratin.It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages.Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.
Their KRT17 high PTEN low phenotype is consistent with a cellular reprogramming during dedifferentiation. Using a 3D organoid model, we demonstrate that IPF-ABCs give rise to more bronchospheres ...
Title: Interference KRT17 reverses doxorubicin resistance in triple-negative breast cancer cells by Wnt/β-catenin signaling pathway. Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis.
The KRT17 gene mutations responsible for pachyonychia congenita change the structure of keratin 17, preventing it from interacting effectively with keratin 6b and interfering with the assembly of the keratin intermediate filament network. Without this network, skin cells become fragile and are easily damaged, making the skin less resistant to ...
KRT17 is an important member of the type I keratin family and is mainly expressed in basal cells of the epithelium, especially in keratinocytes . Mutations in the KRT17 gene result in alterations in the structure of KRT17, which disrupts the integrity of the epidermis and can lead to the development of genetic disorders of the skin, such as ...
KRT17 is upregulated in gastric adenocarcinoma and is associated with tumor progression. mutation of KRT17 may play a major role in the pathogenesis of this pedigree with pachyonychia congenita type 2. Overexpression of KRT17 is associated with basal-like phenotype in breast cancer. higher expression in the fetal skin than in adult skin
KRT17 (PCHC1) protein expression summary. Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape a nd orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Briefly, ∼8-wk-old Krt17 +/−, Krt17 −/−, and Krt17 ΔNLS/ΔNLS mice (both male and female) were anesthetized using isoflurane, and their back hair was shaved using a hair clipper. Two days after shaving, mice were anesthetized and treated topically with single dose of 20 μg of DMBA in 200 μL of acetone on their back skin.
KRT17 is a multifunctional protein that regulates cell proliferation and growth and may promote tumor occurrence and development. This article analyzes the expression, mutation, prognosis, and molecular mechanisms of KRT17 in various tumors using databases and webservers.