为您找到"
KRT17
"相关结果约100,000,000个
Complete information for KRT17 gene (Protein Coding), Keratin 17, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene. [5][6][7][8] Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex. [8]
The KRT17 gene provides instructions for making a protein called keratin 17 or K17. Learn about this gene and related health conditions.
Gene target information for KRT17 - keratin 17 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
The functional role of airway basal cells has not been comprehensively studied in idiopathic pulmonary fibrosis (IPF). Here, the authors show that airway basal cells of IPF patients display a ...
Overexpression of KRT17 is common in NSCLCs and indicates poor prognosis. Overexpression of KRT17 enhances the proliferation and invasiveness of NSCLC cells by activating the Wnt signaling pathway and EMT process. KRT17 is a potential indicator of NSCLC progression and poor survival.
Overexpression of KRT17 enhanced, while KRT17 knockdown inhibited, the proliferation and invasiveness of lung cancer cells. Overexpression of KRT17 up-regulated β-catenin activity and levels of Wnt target genes, such as cyclin D1, c-Myc, and MMP7.
KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1-mediated transformation function but via a mechanism independent of AKT signaling.
KRT17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Covello et al. (1998) described 3 unrelated kindreds carrying KRT17 mutations. Two of these families had identical missense mutations (R94C; 148069.0006) in the 1A domain of KRT17.
The mechanism of KRT17 in cells (U: ubiquitin; P: phosphorylated; D: degradation; M: mature fully polymerized keratin filaments; ?: unknown). Role of Keratin 17 in a Variety of Cancers A growing body of evidence has shown that KRT17 is abnormally expressed in a variety of human malignant tumours, suggesting that KRT17 is an oncogene (Liu et al., 2018; Chen et al., 2020; Chivu-Economescu et al ...