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SDAB 115
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Human epidermal growth factor receptor type 2 (HER2) is overexpressed in various cancers; thus, HER2-targeting single-domain antibodies (sdAb) could offer a useful platform for radioimmunotherapy. In this study, we optimized the labeling of an anti-HER2-sdAb ...
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Abstract. Human epidermal growth factor receptor type 2 (HER2) is overexpressed in various cancers; thus, HER2-targeting single-domain antibodies (sdAb) could offer a useful platform for radioimmunotherapy. In this study, we optimized the labeling of an anti-HER2-sdAb with the α-particle-emitter 225Ac through a DOTA-derivative. The formed radioconjugate was tested for binding affinity ...
Schematic representation of the diverse formats of single-domain antibodies in solid tumor treatment. sdAb-drug conjugates are composed of sdAb that targets tumor antigens and payloads, including toxins, chemotherapeutic compounds, photosensitizers and therapeutic radionuclides.
We recently reported a first-in-human PET study with 68 Ga-labeled anti-HER2 sdAb 2Rs15d for breast cancer imaging (18, 19). 2Rs15d was initially selected because of its non-competing character with trastuzumab and pertuzumab for HER2-binding (20) and could therefore have its use as a therapeutic in tumors resistant to these agents.
The radiolabelled sdAb was purified using three disposable desalting Hitraps in series and collected in a final formulation of 5 mg/mL Na-ascorbate in NaCl 0,9%. Radiochemical purity (RCP) of [18 F]FB-hTIGIT sdAb was performed by size-exclusion chromatography.
作品番号SDAB-115是由松本いちか出演的日本电影，于2020-01-23 (JP)发行，全片片长130分，由SODクリエイト厂商制作
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What country is this movie from? 'SDAB-115 Ichika Matsumoto SOD Create HD 2020 SubRip .srt' was first produced and released in Japan with the 21 Jan, 2020 release date.
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