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SOD1 is a gene that encodes superoxide dismutase 1, an enzyme that protects cells from oxidative stress. Mutations in SOD1 are linked to amyotrophic lateral sclerosis, Parkinson's disease and other disorders.
SOD1 is a gene that encodes a protein that destroys free superoxide radicals in the body and has antimicrobial activity. It is associated with amyotrophic lateral sclerosis and other diseases, and has various aliases, pathways, and regulatory elements.
The SOD1 gene encodes an enzyme that breaks down toxic oxygen molecules in cells. Mutations in this gene can cause amyotrophic lateral sclerosis (ALS), a neurological disorder that affects motor neurons.
Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower motor neurons. The clinical ...
SOD1 is a homodimeric metalloenzyme, in which the two subunits of 16 kDa (153 amino acids in the human isoform) are connected by a disulfide bridge [17]. Each subunit is formed by a β-barrel core and seven loops at the edge stabilized by an intramolecular disulfide bond, a binuclear metal binding site, and a series of hydrogen bonds.
The canonical role of superoxide dismutase 1 (SOD1) is as an antioxidant enzyme protecting the cell from reactive oxygen species toxicity. SOD1 was also the first gene in which mutations were found to be causative for the neurodegenerative disease amyotrophic lateral sclerosis (ALS), more than 20 ye …
Certain genetic variations (SNPs) in SOD1, SOD2, and SOD3 may weaken antioxidant defenses, increasing susceptibility to arthritis. SOD1 Variants: Some mutations in SOD1 have been linked to neurodegenerative conditions like ALS, but they may also contribute to increased oxidative stress in joints, potentially exacerbating arthritis.
Pathogenic variants in the superoxide dismutase 1 (SOD1) gene were the first identified genetic cause of amyotrophic lateral sclerosis (ALS), in 1993. This discovery enabled the development of transgenic rodent models for studying the biology of SOD1 ALS. The understanding that SOD1 ALS is driven by a toxic gain-of-function mutation has led to therapeutic strategies that aim to lower ...
SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme for maintaining cellular redox homeostasis. SOD1 dysregulation ...
Scientists at the University of Sydney have uncovered a malfunctioning version of the SOD1 protein that clumps inside brain cells and fuels Parkinson's disease. In mouse models, restoring the ...