为您找到"
TLR4
"相关结果约100,000,000个
TLR4 is a protein that recognizes bacterial components and triggers inflammation. Learn about its structure, function, ligands, signaling pathways and role in diseases.
TLR4 (Toll Like Receptor 4) is a Protein Coding gene. Diseases associated with TLR4 include Macular Degeneration, Age-Related, 10 and Pertussis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and lipopolysaccharide binding. An important paralog of this ...
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane's surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation ...
Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response.
TLR4 signaling contributes to the impairment of both vascular and lymphatic endothelial barriers, providing new insights into endothelial dysfunction in sepsis-induced ALI.
Abstract Toll-like receptor 4 (TLR4) is expressed in a wide variety of cells and is the central component of the mammalian innate immune system. Since its discovery in 1997, TLR4 has been assigned an ever-increasing number of functions that extend from pathogen recognition to tissue damage identification and promotion of the intrinsic "damage repair response" in pain, intestinal ...
TLR4 polymorphism, especially TLR4 rs4986791, may be associated with increased susceptibility to pulmonary tuberculosis, and the C allele of rs4986791 is a promising protective factor for tuberculosis susceptibility in a Saudi population.
Cryo-EM structures reveal how synthetic glycolipids bind to and activate the immune receptor TLR4/MD-2 in both humans and mice, providing a structural basis for the design of cross-species TLR4 ...
Understanding how TLR4 agonists function and their applications can shed light on the future of medical treatments and preventive measures. TLR4 is a type of toll-like receptor, which is a class of proteins playing a crucial role in the immune system by recognizing pathogens and activating immune responses.
TLR4 is a single-pass transmembrane protein whose structure and function as a pattern recognition receptor (PRR) are highly conserved in mammals.