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TLR4
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TLR4 plays an important role in the process of mouse bone marrow-derived dendritic cell maturation induced by beta2GPI; In a large, well characterised group of haemochromatosis subjects did not demonstrate any relationship between TGF-beta/TLR4 gene polymorphisms and hepatic fibrosis or cirrhosis.
TLR4 is a protein that recognizes bacterial components and triggers inflammation. Learn about its structure, function, ligands, signaling pathways and role in diseases.
TLR4 (Toll Like Receptor 4) is a Protein Coding gene. Diseases associated with TLR4 include Macular Degeneration, Age-Related, 10 and Pertussis.Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.Gene Ontology (GO) annotations related to this gene include signaling receptor activity and lipopolysaccharide binding.
Clinical resource with information about TLR4, Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium., Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance., Novel genetic loci identified for the pathophysiology ...
Learn the definition, function and expression of TLR4, a transmembrane protein that recognizes pathogens and activates innate immunity. Find references and a biomedical dictionary of biological terms.
Similarly, TLR4‐deficient mice had impaired survival with higher bacterial loads and diminished production of inflammatory mediators, indicating that TLR4 signalling is required to induce a protective immune response to common GNB.37 Based on these reports, the dual role of TLR4 in infectious pneumonia seems to be managed by the inhibitory or ...
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane's surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, …
TLR4 signaling enhances CD4 + T-cell activation. (A) Sorted naïve CD4 + T cells were differentiated under various Th conditions for 4 d followed by intracellular cytokine staining.(B) Naïve CD4 + T cells from WT or Tlr4 −/− mice were treated 3 d with media, 1 μg/mL αCD28, or αCD28 + αCD3 in the absence or presence of LPS.Data are presented as mean + SD for triplicate determinations ...
TLR4, which is mainly expressed on cells of the immune system—including monocytes, macrophages and dendritic cells—has long been recognized as a PRR that senses lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria. Activation of TLR4 by LPS, its best studied ligand, is a multistep process.
Toll样受体4（英語： Toll-like receptor 4 ）是由人类基因 TLR4 编码的蛋白质，是一种膜蛋白质，也被称为CD284（分化簇284，cluster of differentiation 284），是模式识别受体中Toll样受体（TLR）家族的成员，可结合其配体脂多糖（LPS）激活NF-κB信号通路，在先天免疫系統中起到重要作用 [6] 。