为您找到"
TREX1
"相关结果约100,000,000个
TREX1 is a gene that encodes a DNA exonuclease involved in proofreading, homology-directed repair and cell death. Mutations in TREX1 can cause Aicardi-Goutieres syndrome, chilblain lupus, RVCL and other conditions.
Three prime repair exonuclease 1 (TREX1) is a widely expressed protein that acts as part of the SET complex in granzyme A-mediated apoptosis to degrade single-stranded DNA. TREX1 encodes a 3'-exonuclease 1 protein that removes nucleotides from the 3' ends of DNA molecules to remove unneeded fragments that may form during DNA replication. The TREX1 gene has also been found to play a role in ...
TREX1 is a gene that encodes a nuclear protein with 3' exonuclease activity involved in DNA repair and immune system. Learn about its aliases, disorders, pathways, products, publications, and more on GeneCards.
The TREX1 gene provides instructions for making the 3-prime repair exonuclease 1 enzyme. Learn about this gene and related health conditions.
TREX1 is a cytosolic DNA nuclease and the genetic mutations of it are linked to autoimmune diseases. Here the authors determine the first structure of the human TREX1-DNA complex, and provide a ...
Thus, we hypothesize TREX1 exonuclease inhibition as a novel immunotherapeutic strategy. We present data demonstrating antitumor immunity in the TREX1 D18N mouse model and discuss theory surrounding the best strategy for TREX1 inhibition. Potential complications of TREX1 inhibition as a therapeutic strategy are also discussed.
Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 ...
Trex1 is a cytosolic exonuclease that limits sensing of intracellular DNA. Yan and colleagues show that Trex1 deficiency spontaneously heightens adaptor STING-dependent proinflammatory responses ...
The ER-associated nuclease TREX1 guards against immune disease by clearing immunostimulatory DNA from the cytosol. Mohr et al. identify a key role for the ER in limiting immune activation by directing TREX1 engagement with DNA substrates such as micronuclei.
TREX1 is an exonuclease that degrades extranuclear DNA species in mammalian cells. Herein, we show a novel mechanism by which TREX1 interacts with the BiP/GRP78 and TREX1 deficiency triggers ER stress through the accumulation of single-stranded DNA ...