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Vanin-1
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Other vanin molecules include mVanin 3, a rat vanin 1 orthologue, a drosophila homologue, and bottlenose dolphin vanin 1 [11,12]. mVanin 3 mRNA has been detected in lung tissue, liver, and blood, while its gene expression is completely absent in kidney [6,8,9]. Among these genes belonging to the pantetheinase family, murine and human vanin 1 ...
Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene. [5] [6]This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase.The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking.
The enzyme vascular non-inflammatory molecule-1 (vanin 1) is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney. Its major function is related to its pantetheinase activity; vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precurs …
vanin-1 and vanin-3 are induced at the mRNA and protein level by psoriasis-associated proinflammatory cytokines (Th17/Th1) but not by Th2 cytokines. missense SNP rs2272996 (or N131S) in the VNN1 gene was significantly associated with hypertension in African Americans and the association was replicated in Mexican Americans; a non-significant ...
vanin 1 orthologue, a drosophila homologue, and bottlenose dolphin vanin 1 [11,12]. mVanin 3 mRNA has been detected in lung tissue, liver, and blood, while its gene expression is completely absent ...
Urinary vanin-1 and long-term mortality Kaplan-Maier curve for the prediction of all-cause survival, cardiovascular mortality as well as subgroup analyses for eGFR < 60 and eGFR > 60 according to uVNN1/Cr over 10 years. Tertiles were compared using the log-rank test (p-value).
The Vanin family contains three homologous genes: Vanin1 (VNN1), Vanin2 (VNN2) and Vanin3 (VNN3). Among them, human VNN1 and VNN2 are both outer membrane enzymes, and VNN3 may encode proteins other than pancytokinase or may be a pseudogene (Kaskow et al., 2012).VNN1, also known as vascular noninflammatory molecule-1, is a pantothenic mercaptoethylamine hydrolase that converts pantothenic acid ...
Mechanistically, Vanin-1 induces PPARγ activity and subsequently facilitates its activation on the proximal promoters of lipolytic genes. Thus, an essential role of Vanin-1 in the regulation of lipolysis and adiposity is revealed, and a functional RNA delivering strategy for specific intervention of Vanin-1 expression in WAT is shown.
Vanin-1 is a membrane-anchored pantetheinase highly expressed in the gut and liver. It hydrolyzes pantetheine to pantothenic acid (vitamin B5) and the low-molecular-weight thiol cysteamine. The latter is believed to be a key regulating factor of several essential metabolic pathways, acting through sulfhydryl-disulfide exchange reactions between ...
Recently, vanin-1 was identified as another AKI biomarker, and urinary vanin-1 has been shown to have superior predictive value for cisplatin-induced AKI than KIM-1, NGAL, or NAG [12,13,14]. Vanin-1 is highly and selectively expressed in renal tubular epithelial cells . Therefore, tubular injury caused by increased intra-tubular pressure might ...