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Basic Local Alignment Search Tool - BLAST

The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.

UniProt

BLAST; Align; Peptide search; ID mapping; SPARQL; Release 2024_06 | Statistics. Help. UniProt website home page. Find your p r o t e i n. UniProtKB. ... (Swiss-Prot) 572,619. Unreviewed (TrEMBL) 253,682,368. Species Proteomes. Protein sets for species with sequenced genomes from across the tree of life. Protein Clusters

UniProt BLAST - SIB Swiss Institute of Bioinformatics - Expasy

BLAST sequence similarity search against UniProtKB or taxonomic subdivisions, complete proteomes, UniRef, PDB or UniParc - on the UniProt web site. Browse the resource website Developed by the Swiss-Prot group .

UniProtKB/Swiss-Prot - SIB Swiss Institute of Bioinformatics - Expasy

UniProtKB/Swiss-Prot is the expertly curated component of UniProtKB (produced by the UniProt consortium). It contains hundreds of thousands of protein descriptions, including function, domain structure, subcellular location, post-translational modifications and functionally characterized variants.

Protein BLAST: search protein databases using a protein query

PSI-BLAST allows the user to build a PSSM (position-specific scoring matrix) using the results of the first BlastP run. PHI-BLAST performs the search but limits alignments to those that match a pattern in the query. DELTA-BLAST constructs a PSSM using the results of a Conserved Domain Database search and searches a sequence database.

Help results - UniProt

Tutorial/Video Select the Blast tab of the toolbar to run a sequence similarity search with the. Saving proteins with the UniProt basket. subset of your proteins (Align, ... How is orthology established in UniProtKB/Swiss-Prot? sequence similarity search programs such as BLAST. Orthology relationships are then verified manually using.

Psi-blast - Embl-ebi

PSI-BLAST allows users to construct and perform a NCBI BLAST search with a custom, position-specific, scoring matrix which can help find distant evolutionary relationships. ... (Protein) UniProtKB/Swiss-Prot (The manually annotated section of UniProtKB) Input sequence . Paste your sequence here - or use the example sequence. Use the example ...

SWISS-PROT: When and How to Use It - CUSABIO

SWISS-PROT establishes cross-references with a variety of databases databases, such as the protein tertiary structure library PDB, the human gene Mendelian genetic database (MIM), the protein type and the site library (PROSITE), which can directly access related entries in other databases. ... Blast: With the Basic Local Alignment Search Tool ...

Why is UniProtKB composed of 2 sections, UniProtKB/Swiss-Prot and ...

The TrEMBL section of UniProtKB was introduced in 1996 in response to the increased dataflow resulting from genome projects. It was already recognized at that time that the traditional time- and labour-intensive manual curation process which is the hallmark of Swiss-Prot could not be broadened to encompass all available protein sequences.

UniProtKB - SIB Swiss Institute of Bioinformatics | Expasy

e.g. BLAST, UniProt, MSH6, Albumin... UniProtKB Proteins & Proteomes Database The UniProt Knowledgebase is a central hub for the collection of functional information on proteins with accurate, consistent and rich annotation. ... Developed by the Swiss-Prot group and the UniProt Consortium partners at EMBL-EBI and PIR, and supported by the SIB ...

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