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caerulein
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Ceruletide, also known as caerulein, is a decapeptide that stimulates digestive secretions and smooth muscle. It is used to induce pancreatitis in animal models and was discovered from the Australian green tree frog (Ranoidea caerulea).
The major use of caerulein in pancreatic studies over the last 25 years has been to induce a model of experimental pancreatitis. In 1977 Horst Kern and colleagues showed that a continuous iv infusion of supramaximal caerulein into rats (5 μg/kg per hour) induced edematous pancreatitis with a tenfold increase in plasma amylase, and the appearance of large cytoplasmic vacuoles in pancreatic ...
Caerulein is a kind of ten-peptide substances, the analog of cholecystokinin, and possesses different biological activities[36,37]. Caerulein can stimulate the acinar cells to excrete a large amount of digestive enzyme and pancreatic fluid, resulting in a mild edematous pancreatitis characterized by a higher serum amylase level, interstitial ...
Caerulein is a decapeptide that contains the C-terminal four aa sequence (Trp-Met-Asp-Phe-NH 2) that is conserved in the vertebrate gastrin and CCK. A pyroglutamate residue is present in the N-terminus, and a C-terminal phenylalanine residue is amidated. Caerulein possesses a sulfated tyrosine at the seventh residue from the C-terminus (Fig ...
Two preprocaeruleins, caerulein precursor fragment (CPF)-st6 and CPF-st7, have been reported in the western clawed frog Silurana tropicalis (Figure 20C.2) [3].The precursor of caerulein contains a signal peptide, an antimicrobial peptide called caerulein precursor fragment, and mature caerulein (Figure 20C.2).Sauvage's leaf frog, Phyllomedusa sauvagei, possesses a caerulein-like nonapeptide ...
Caerulein acts according to its similarity to the natural gastrointestinal peptide hormone cholecystokinin. Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin is secreted by the duodenum, the first segment of the small intestine.
Caerulein is a decapeptide that is synthesized and released from the skin cells of some frog species. It has a conserved sequence with vertebrate gastrin and CCK, and can activate these receptors in mammals.
The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of int …
Caerulein is an analogue of cholecystokinin (CCK), which directly stimulates acinar enzyme production and secretion in rodents. When administered at supra-physiologic levels, caerulein promotes excessive digestive enzyme production, ultimately leading to the improper activation of these zymogens within the cell by lysosomal cathepsin-B (24, 25).
Abstract. Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells into the pancreas.