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Caspase 1 is an enzyme that cleaves inflammatory cytokines and Gasdermin D, and initiates inflammasome formation and pyroptosis. Learn about its cellular expression, regulation, inhibition and role in cell immunity.
Caspase-1 is one of the main mediators of inflammatory caspases and has become a correspondent with inflammation, cell death, and several inflammatory diseases. In this review, we systematically summarize both original and recent advances in caspase-1 to provide references for a better understanding …
HIV-1 Vpr-induced apoptosis involves activation of caspases and the involvement of caspase 1 is suggested based on studies with mice transgenic for the HIV-1 vpr gene: PubMed: Go to the HIV-1, Human Interaction Database . Pathways from PubChem. Go to the top of the page. Interactions. Go to the top of the page Help. Products Interactant Other Gene
CASPASE-1. Caspase-1 is a cysteine protease that converts the inactive proform of IL-1β to the active inflammatory cytokine and hence represents an attractive target for the modulation of the effects of IL-1β (12,13).The therapeutic value of caspase-1 inhibitors may also be enhanced by indirect effects of caspase-1 inhibition on levels of IL-1 α (14) as suggested by data from caspase-1 ...
Caspase-1: Following stimulation by a myriad of microbial and endogenous signals, an assembly of the multiprotein platform named "inflammasome" occurs via the activation of several Nod-like receptors (Franchi et al., 2009). Caspase-1 is the core component of all inflammasome complexes that regulate the activation, production, and secretion ...
Caspase-1 (Casp-1), a protease enzyme, plays a critical role during inflammatory processes by initiating programed cell death and promoting the cleavage of pro-interleukin (IL)-1β into its active form, IL-1β, through inflammasome assembly. Here, we aimed to elucidate the complex mechanisms involved in IVH-induced inflammation, leukocyte ...
This implicates Caspase-1, a cysteine-aspartic acid protease responsible for cleaving the precursors of IL-1β and Gasdermin D, inducing pyroptosis. CASP1 is typically expressed as a zymogen (Pro-CASP1) that can be cleaved into an active enzyme (CASP1). There is an urgent need for targeted therapies that restore dysregulated innate immune and ...
Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis, a caspase-1-dependent type of programmed cell death, has been identified that is able to support secreted IL-1 and IL-18 in triggering an inflammatory response.
Caspase-1 was cloned nearly three decades ago as the Interleukin-1β Converting Enzyme (ICE) in a hunt for the enzyme that is responsible for the proteolytic maturation of the pro-inflammatory cytokine IL-1β in human monocytes (Lamkanfi and Dixit, 2014, 2017). The subsequent generation of caspase-1-deficient mice confirmed the essential role ...
Caspase-1, however, seems to be uniquely involved in participating in the inflammatory response by cleaving the precursors of IL-1 beta, IL-18, and IL-33. Indeed, the rate-limiting step in inflammation due to IL-1 beta or IL-18 is the activation of caspase-1. Inactive pro-caspase-1 is converted to an active enzyme via dimerization, followed by ...