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CD33 is a transmembrane protein that binds sialic acids and inhibits phagocytosis. It is expressed on myeloid cells and some lymphoid cells, and is the target of an antibody-drug conjugate for acute myeloid leukemia.
CD33 is a protein that binds to sialic acid and regulates innate immunity and microglial activation. It is also associated with Alzheimer's disease (AD) risk and Aβ clearance, and its expression and splicing are influenced by genetic variants.
CD33 is a transmembrane protein that is found on cells of myeloid lineage. It is also intensely expressed on acute myeloid leukemia (AML) progenitor cells but not on normal stem cells. It internalizes on binding and dimerization, making it a specific and ideal target for AML therapeutics and drug delivery. Several targeted therapies have been ...
CD33 is a protein coding gene that encodes a sialic acid-binding immunoglobulin-like lectin involved in immune regulation and cell-cell interactions. It is associated with several diseases, such as cardiovascular system disease and myeloid leukemia, and has multiple aliases, pathways, and products.
CD33 is a myeloid differentiation antigen that is displayed on acute myeloid leukemia (AML) blasts in most patients and, possibly, leukemic stem cells in some, and has thus served as target for antibody-based therapies for many years. Validation for this approach comes from the antibody-drug conjugate, gemtuzumab ozogamicin, which improves ...
CD33 is a classic myeloid antigen that is expressed on various hematopoietic cells and some tumors. Learn about its function, clinical features, positive and negative staining patterns, and applications in pathology and stem cell selection.
CD33 is a transmembrane protein that belongs to the Siglecs (sialic-acid-binding immunoglobulin-like lectins) family[].In normal individuals, expression of CD33 is associated with myeloid maturation and is present on multipotent myeloid precursors and maturing monocytes and granulocytes, but is also found on some lymphoid cells [2-4].The majority of cases of acute myeloid leukemia (AML) also ...
The fact that all M3 AMLs are CD33 + has previously been reported. 11, 51 Interestingly, we observed high expression of CD33 in patients with FLT3 mut/wt ratios >0.78 and in patients with monosomy ...
CD33 is a transmembrane receptor of the innate immune system that is expressed on the surface of peripheral monocytes and microglial cells in the brain. CD33 was first implicated in Alzheimer's disease genetics in 2008, and in 2011 reached genome-wide significance in large GWAS in the U.S. and Europe. Since then, CD33 has been further ...
CD33 is a 67-kD transmembrane glycoprotein expressed on myeloid cells and some lymphoid cells. It is involved in cell adhesion, apoptosis, and drug resistance in AML, and is a target for bispecific antibodies and CAR-T cell therapy.