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NT5E, also known as CD73, is an enzyme that converts AMP to adenosine and a marker of lymphocyte differentiation. It is involved in immunosuppression, inflammation, and cancer, and has been proposed as a drug target for some tumours.
CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis. The inhibition of CD73, in combination with immune checkpoint blockade, targeted therapy or conventional therapy, improves antit …
CD73, known as ecto-5′-nucleotidase, is a cell surface glycosylphosphatidlinositol-anchored glycoprotein. CD73 is essential for the generation of extracellular adenosine from 5′-adenosine monophosphate (5′-AMP) through the coordinated action of CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1; ecto-NTPDase1) that catalyzes the phosphohydrolysis of ATP and ADP to AMP) [1,2].
Although CD73 is the main AMP-degrading enzyme, adenosine is still generated by tissue-nonspecific alkaline phosphatase (TNAP) when CD73 is absent, as shown in CD73 knockout mice 55,56 and in ...
CD73 is an ecto-5′-nucleotidase (NT5E) that generates extracellular adenosine (eADO) through coordination with ecto-nucleoside ATPases, including ectonucleoside triphosphate diphosphohydrolases1 ...
CD73 is a key enzyme in extracellular adenosine production, which regulates immunosuppression and tumor progression. This review discusses the role of CD73 expression and activity as prognostic and predictive biomarker in various types of cancers.
CD73, known as ecto-5′-nucleotidase (ecto-5′-NT, EC 3.1.3.5) is a glycosyl-phosphatidylinositol (GPI)-linked 70-kDa cell surface enzyme found in most tissues (6, 7). CD73, originally defined as a lymphocyte differentiation antigen, is thought to function as a co-signaling molecule on T lymphocytes and as an adhesion molecule that is ...
CD73 is a 70-kD, glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, also known as ecto-5′-nucleotidase (ecto-5′-NT, EC 3.1.3.5), plays a crucial role in switch on adenosinergic signaling. CD73 has both enzymatic and nonenzymatic functions in cells . As a nucleotidase, CD73 catalyzes the hydrolysis ...
CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune cells (9-11).Abnormal accumulation of CD73 in tumors has been connected to poor prognosis in various cancers, especially in TNBC (12-14).The essential role of CD73 is to produce extracellular adenosine from adenosine monophosphate (AMP) through functional coordination with CD39 (15, 16).
CD73 is a multifunctional ectoenzyme that converts ATP to adenosine and promotes tumor growth and metastasis. This review discusses the roles of CD73 on tumor and immune cells and the therapeutic potential of targeting CD73 for cancer treatment.