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Learn about ceRNA, a mechanism of RNA regulation where different RNA transcripts compete for shared miRNAs. Find out the models, evidence, debate and applications of ceRNA in molecular biology.
In contrast to the lnc-ceRNA HULC that is upregulated in cancer cells, the ceRNA PTCSC3 was found to be dramatically downregulated in thyroid cancers and to exert a tumor-suppressing effect. The overexpression of PTCSC3 in thyroid cancer cells can induce cancer cell growth inhibition, cell cycle arrest and apoptosis by acting as a sponge of miR ...
8. Conclusion. In this review, we present a genome-wide molecular interaction dominated by ncRNAs in a deep-going extent of post-transcriptional regulation regarding different types of cancer, where detailed mechanisms of the dynamic network, powerful predicting tools, and typical ceRNA crosstalk in pathogenesis, progression, and drug resistance in cancer have all together sketched out an ...
CeRNA activity is influenced by multiple factors such as the abundance and subcellular localisation of ceRNA components, binding affinity of miRNAs to their sponges, RNA editing, RNA secondary structures and RNA-binding proteins. Aberrations in these factors may deregulate ceRNA networks and thus lead to human diseases including cancer.
Competing endogenous RNA (ceRNA) is a group of RNAs that compete with miRNA for mRNA translation. Learn how ceRNA regulates miRNA activity and how it is involved in cardiovascular disease and cancer.
The ceRNA networks were visualized by Network Workbench and Cytoscape 3.0.2 and topology analysis was performed by the package of 'igraph' in R language. To estimate the similarity of two cancer ceRNA networks, we calculated the number of edges that are present in both networks (common ceRNA interactions) and Simpson index was used.
Name Description type References ceRNABase: ceRNABase is designed for decoding Pan-Cancer ceRNA networks involving lncRNAs and mRNAs by analyzing 5599 tumor and normal samples and 108 CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) datasets.: database and server [3]cefinder: Competing endogenous RNA database: predicted ceRNA candidates from genome.
Although it has been proposed that ceRNA crosstalk may be limited to a small subset of transcripts, owing to factors such as miRNA abundance, ceRNA abundance and subcellular localization 10,13 ...
The competitive endogenous RNA (ceRNA) hypothesis suggests an intrinsic mechanism to regulate biological processes. However, whether the dynamic changes of ceRNAs can modulate miRNA activities ...
The ceRNA hypothesis adds a potential mechanism about the regulation of gene expression in tumorigenesis, while further supplies a new opportunity for remedying various human malignancies. In the ...