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Dicer is a ribonuclease that cleaves double-stranded RNA and pre-microRNA into small RNAs, which are involved in gene silencing. Learn about the discovery, structure, function, and regulation of Dicer in humans and other organisms.
Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow function and survival of eukaryotic cells. The type III ribonuclease DICER is widely recognized as a ...
DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. Less commonly observed tumors include ciliary body medulloepithelioma, nasal ...
Dicer is a general name for RNase III endoribonucleases producing small RNAs for RNA silencing pathways. There is a common order of specific modules present in Dicer across eukaryotic kingdoms, which reflects the common order of protein domains in the primary protein sequence. This protein organization constitutes the canonical Dicer architecture, despite some eukaryotic Dicers differing ...
DICER is a vital enzyme in small RNA production. Here the authors show how bipartite pairing rules and dual YCR motifs guide DICER's activity on precursor microRNAs.
Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow function and survival of eukaryotic cells. The type III ribonuclease DICER is widely recognized as a key step in the production of miRNAs and siRNAs, alth …
DICER is a ribonuclease that processes miRNAs and siRNAs, and has non-canonical roles in DNA repair and apoptosis. This review summarizes the structural features, canonical and non-canonical functions, and regulatory mechanisms of DICER, and its impact on health and aging.
Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral activity occurs via small interfering RNA production following cytoplasmic ...
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional ...
Dicer enzyme functions in the processing of pre-miRNAs into functional miRNAs. This multifaceted enzyme, belonging to the RNase III family