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DISC1 is a protein encoded by a gene on chromosome 1 that regulates various cellular functions. Mutations in DISC1 have been linked to schizophrenia, depression, bipolar disorder, and other conditions in a Scottish family with a translocation.
DISC1 is a protein coding gene involved in neurogenesis and schizophrenia. Learn about its aliases, disorders, domains, drugs, expression, function, genomics, localization, orthologs, pathways, products, proteins, publications, sources, summaries, transcripts and variants.
Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein interacting with proteins ...
In the history of molecular psychiatry, DISC1 emerged as one of the most popular leads to explore molecular pathways underlying the pathophysiology of major mental conditions. 6 Although its significance in the unique Scottish pedigree is still undoubted, great advances in genome-wide association studies on schizophrenia and other major mental ...
Abstract. Psychiatric genetics research, as exemplified by the DISC1 gene, aspires to inform on mental health etiology and to suggest improved strategies for intervention. DISC1 was discovered in 2000 through the molecular cloning of a chromosomal translocation that segregated with a spectrum of major mental illnesses in a single large Scottish family.
Disrupted in schizophrenia 1 (DISC1) is well established as a genetic risk factor across a spectrum of psychiatric disorders, a role supported by a growing body of biological studies, making the DISC1 protein interaction network an attractive therapeutic target. By contrast, there is a relative defi …
DISC1 also inhibits the formation of the β-catenin degradation complex by binding GSK3β, therefore leading to β-catenin stabilization and up regulation of Wnt signaling. DISC1 and APP interact with phosphorylated Dab1, a key downstream target of Reelin.
Family Evidence. DISC1 was first identified in genetic studies of a large Scottish family in which a chromosomal translocation was found to segregate with mental illness. Microdissection of the translocated chromosomes identified the breakpoint on chromosome 1 at 1q42.2, 4 and subsequent analysis identified 2 genes directly disrupted by the translocation, Disrupted in Schizophrenia 1 and 2 ...
Disc1 was genotyped using snps to determine its association to schizophrenia. Possibility that mutations in the DISC1 gene can increase the risk for schizophrenia and related disorders. Two additional loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to ...
Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points toward DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to ...