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DISC1 is a protein encoded by a gene on chromosome 1 that regulates various cellular functions. Mutations in DISC1 have been linked to schizophrenia, depression, bipolar disorder, and other conditions in a Scottish family with a translocation.
DISC1 is a protein coding gene involved in neurogenesis and schizophrenia. Learn about its aliases, disorders, domains, drugs, expression, function, genomics, localization, orthologs, pathways, products, proteins, publications, sources, summaries, transcripts and variants.
DISC1 interacts with many proteins, including several synaptic proteins 21,22.Among the synaptic proteins identified as putative DISC1 partners by yeast two-hybrid screenings, Kal-7, a GDP/GTP ...
The disrupted-in-schizophrenia 1 (DISC1) gene has been named for the gene at the point of balanced translocation, which is likely to be deficient in schizophrenia. It encodes a multifunctional scaffold protein. The DISC1 protein interacts with several proteins and is involved in essential nervous system functions. DISC1 is highly expressed ...
Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. In a yeast 2-hybrid assay of a human whole brain cDNA library, DISC1 interacted with a variety of cytoskeletal proteins. One of these, NUDEL (NDEL1; 607538), is associated with cortical development ...
Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene implicated in major mental illnesses, such as schizophrenia, depression, bipolar disorder and autism, but the link between this protein and the pathology of these diseases remains unclear.
In the year 2000, a group reported a molecule with the fascinating name, Disrupted-in-Schizophrenia 1 (DISC1), based on the unique finding of a familial aggregation of major mental illnesses. 1 It was very reasonable that people suddenly jumped onto this fascinating molecular lead, given that there had been a long-term gap in understanding ...
Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the ...
Disrupted in schizophrenia 1 protein Curated. Gene names. Name. DISC1 Imported. Synonyms. KIAA0457. Organism names. Taxonomic identifier. 9606 . Organism. Homo sapiens (Human) Taxonomic lineage. Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini ...
The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2. More recently, DISC1 was linked to schizophrenia, broadly defined, in the general Finnish population, through the undertransmission to ...