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ETV2 (ETS Variant Transcription Factor 2) is a Protein Coding gene. Diseases associated with ETV2 include Hypoplastic Left Heart Syndrome and Polydactyly.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding.An important paralog of this gene is ETS1.
Mechanistically, ETV2 directly binds promoters or enhancers of genes that are critical for endothelial and hematopoietic cell lineages. Similar findings were reported by two groups as the two generated Etv2 gene trap mice and Etv2-gfp knockin mice, respectively (Ferdous et al., 2009; Kataoka et al., 2011).
ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Steimle JD, et al. Cell Rep, 2023 Jun 27. PMID 37330911, Free PMC Article; ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming. Kim TM, et al. Stem Cell Res Ther, 2023 Mar 16. PMID 36927793, Free PMC Article
Function of ETV2. (A) In early embryogenesis, ETV2 plays indispensable roles for the establishment of the cardiovascular system through the direct binding to promoters or enhancers of genes critical for the hematopoietic and endothelial cell lineages.Recent reports suggest that ETV2 can form an active transcriptional complex at least with OVOL2, GATA2, FOXC2 or TET1/2.
The ETS transcription factors are known to play critical roles during EC specification and the establishment of the cardiovascular system [].We and other laboratories have identified Etv2 (also known as Er71 or ets1-related protein, etsrp) as a novel ETS member with an irreplaceable role in embryonic vessel formation [7, 8, 12,13,14].The significance of Etv2 in vessel development was first ...
ETV2 reprograms fibroblasts into endothelial cells. We isolated E13.5 embryonic fibroblasts from the iHA-Etv2 mouse, which inducibly overexpresses ETV2 following administration of doxycycline (Dox ...
Etv2, which is silent in homeostatic HSCs, was transiently activated in regenerating HSPCs and was required for the HSC expansion and regeneration following bone marrow transplantation or haematopoietic injury. REVIEW. the interplay among the ETS transcription factor ETV2, vascular endothelial growth factor, and its receptor VEGFR2/FLK1 is ...
ETV2 has drawn a great deal of attention as an important regulator for embryonic vessel and blood cell development. Structurally, ETV2 shares a conserved ETS DNA binding domain with other ETS factors but does not exhibit any similarities outside this domain (Brown and McKnight, 1992; De Haro and Janknecht, 2002; 2005).Although identified as a testis specific protein in adults (Brown and ...
Fifteen days after ETV2 induction into HAFs, CD31 + cells that also expressed VE-cadherin were isolated, and on day 25, the expanding CD31 + cells were purified again (Fig. 5 A and B). ETVECs continued to multiply beyond 50 d after ETV2 transduction (Fig. 5C) and exhibited a cobblestone-like morphology (Fig. 5D and SI Appendix, Fig. S6A).
ETV2 (Ets variant transcription factor 2), an Ets-related transcription factor, is expressed transiently in primitive angioblasts and regulates hematoendothelial lineage specification during embryogenesis. 1 Genetic deletion of Etv2 results in embryonic lethality by E9.5 because of the complete absence of hematoendothelial lineages. 2,3 Studies have demonstrated that ETV2 regulates multiple ...