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Testing for the HER2 status of a breast cancer helps determine which treatment is best. Learn how to ensure the best outcome.
FISH testing can tell your doctor whether you have this type of cancer, called HER2 -positive breast cancer, or a HER2-negative cancer with normal levels of the protein.
Breast Cancer HER2 Status About 15% to 20% of breast tumors have higher levels of a protein known as HER2. These cancers are called HER2-positive breast cancers. Ask your cancer care team about your HER2 status and what it means for you.
A FISH test is used to figure out a breast cancer's HER2 status. It measures the number of HER2 genes in breast cancer cells. If a breast cancer cell has too many copies of the HER2 gene, it makes higher than normal numbers of HER2 proteins. These proteins act as receptors on breast cancer cells and receive signals that stimulate the growth of the cancer.
ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the evaluation of human epidermal growth factor receptor 2 gene (HER2) amplification by fluorescent in situ hybridization (FISH). We retrospectively assessed the impact of these new guidelines by using annotated Breast Cancer International Research Group (BCIRG) -005, BCIRG-006, and BCIRG-007 ...
HER2 FISH positive is defined as an average of >6 HER2 gene copies/nucleus for test systems without an internal control probe or HER2/CEP 17 ratio of more than 2.2, where CEP17 is a centromeric probe for chromosome 17 on which the HER2 gene resides (Fig. 3).
An equivocal FISH result requires additional testing (HER2 IHC, testing another block from the patients tumor, repeat FISH with an alternative chromosome 17 reference probe) to try and resolve the HER2 status for clinical decisions on adjuvant treatment.
A FISH test is a lab test performed on tissue taken from a biopsy or breast cancer surgery, that can confirm breast cancer's HER2 status if other test results are inconclusive.
This test detects amplification of the HER2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded breast cancer tissue specimens. FISH is performed using PathVysion (Abbott Molecular, Inc) probes to the HER2 locus (17q11.2-q12) and the chromosome 17 centromere (D17Z1). Results are reported as a HER2:D17Z1 copy number ratio and interpreted according to ASCO/CAP ...
Leica HER2 FISH System for BONDTM - Interpretation Guide for Breast Cancer Tissue A serial section H&E of the breast tissue specimen should be available for reference to verify the presence of invasive tumor.