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formazan
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Formazan is a compound derived from formazan, a colorless tetrazolium salt. It is used in histochemical methods and viability assays based on its reduction by dehydrogenases and reductases.
Formazan | CH4N4 | CID 9567750 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ...
Learn how formazan compounds are used in biochemical and cell biology studies, with their chemical structure, synthesis methods, and detection techniques. Find out how formazan assays measure cell viability, enzyme activity, and bioimaging.
Formazan is a product of reduction of tetrazolium salts by cells or enzymes. It is used as a marker of cell viability, a probe for reactive oxygen species, and a dye for coordination chemistry.
The formazan derivatives (FM1-FM5) were synthesized by the reaction of benzaldehyde phenylhydrazone with substituted aromatic and hetero aromatic amines. The structures of the synthesized compounds were then elucidated using UV, IR, 1 H NMR and mass spectral data. The synthesized derivatives were screened for anticonvulsant, antibacterial and ...
The quantity of formazan (presumably directly proportional to the number of viable cells) was measured by recording changes in absorbance at 570 nm using a plate reading spectrophotometer. Noncytotoxic Silver and Gold Nanocomposite Hydrogels with Enhanced Antibacterial and Wound Healing Applications
Formazan is a product formed by the cleavage of tetrazolium salts, specifically 3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyl tetrazolium bromide (MTT), by cellular enzymes. The quantity of formazan produced is directly proportional to the number of living cells in culture and can be measured by a microplate reader.
This article surveys the structure, synthesis, properties and applications of formazans and tetrazolium salts, which are organic compounds with redox and biological significance. It also discusses the tautomerism, isomerism and spectroscopy of formazans, and their use as indicators of vitality and anti-cancer drugs.
Misra and Dhar synthesized the two formazan derivatives 13 and 14 by coupling of the corresponding hydrazones each with benzene diazonium salt and screened them for their antiviral activity against vaccinia virus and Ranikhet disease virus in a stationary culture of chorioallantoic membrane of chick embryo. The results revealed that the two ...
The main method of formazan synthesis involves the interaction of bis-diazo salts with methylene-active and methyne compounds, typical yields being within 10-50%. Representatives of the farmazan ...