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GAPDH is an enzyme that catalyzes the sixth step of glycolysis and has various non-metabolic functions. Learn about its structure, function, regulation, and orthologs in different species.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has long been recognized as an important enzyme for energy metabolism and the production of ATP and pyruvate through anaerobic glycolysis in the cytoplasm. Recent studies have shown that GAPDH has multiple functions independent of its role in energy m …
GAPDH is a protein coding gene that encodes a multifunctional enzyme involved in glycolysis, nitrosylation, and antimicrobial activity. Learn about its aliases, disorders, pathways, products, and more from GeneCards database.
GAPDH provided by HGNC Official Full Name glyceraldehyde-3-phosphate dehydrogenase provided by HGNC Primary source HGNC:HGNC:4141 See related Ensembl:ENSG00000111640 MIM:138400; AllianceGenome:HGNC:4141 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage ...
GAPDH is known to interact with tubulin and actin, facilitating microtubule bundling and actin polymerization, respectively. GAPDH may be transported within the cell via microtubule treadmilling. GAPDH also plays an important role in VTCs (v esicular t ubular c lusters) where phosphorylated GAPDH by atypical protein kinase Cι (aPKC) is ...
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may ...
GAPDH is upregulated in multiple cancer types. (A) GAPDH mRNA expression in 33 cancer types based on TCGA and GTEx database. The red and blue dots refer to tumor (T) and normal tissues (N), respectively. (B) Protein-coding transcripts of GAPDH were upregulated in 33 cancer types based on TCGA and GTEx databases. Red and green squares represent upregulation and downregulation, respectively.
GAPDH has been implicated in many diseases, including those of pathogenic, cardiovascular, degenerative, diabetic, and tumorigenic origins. Understanding the mechanisms by which GAPDH can switch between its functions and how these functions are regulated can provide insights into ways the protein can be modulated for therapeutic outcomes.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an important enzyme in energy metabolism with diverse cellular regulatory roles in vertebrates, but few reports have investigated the importance of plant GAPDH isoforms outside of their role in glycolysis. While animals possess one GAPDH isoform, p …
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC 1.2.1.12) is a dynamic, multifunctional protein that is ubiquitously expressed and highly conserved across all kingdoms of life (Stone et al. 1985).In humans, GAPDH is encoded by a single structural gene, located on chromosome twelve, of somatic cells (Bruns et al. 1979).