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GelMA hydrogels can be gained readily by photopolymerization of GelMA prepolymer. Also, the hydrogel properties can be engineered during the preparation processes. Notably, GelMA hydrogels are similar to ECM, and this feature is the basis of further applications in biomedical field.
Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high ...
GelMA is a gelatin derivative that can form photocrosslinked hydrogels with tunable mechanical and biological properties. GelMA hydrogels are widely used for tissue engineering, cell research, drug delivery, and bio-sensing due to their resemblance to ECM and their cell-responsive motifs.
GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective.
In general, GelMA possesses many relevant characteristics to serve as tissue engineering scaffolds. GelMA-based hydrogels are biocompatible, biodegradable, non-cytotoxic, and non-immunogenic. GelMA is also a versatile biomaterial with tunable physicochemical properties, promising remarkable compatibility for a wide spectrum of applications.
Gelatin methacryloyl (GelMA), a photocurable hydrogel, is widely used in 3D culture, particularly in 3D bioprinting, due to its high biocompatibility, tunable physicochemical properties, and excellent formability. However, as the properties and performances of GelMA vary under different synthetic conditions, there is a lack of standardization ...
GelMA is a photocrosslinkable gelatin derivative that can be used for cell culture and tissue engineering. This review covers the preparation methods, properties and applications of GelMA hydrogels, especially in load-bearing tissues such as bone and cartilage.
Gelatin methacryloyl (GelMA) hydrogels have been extensively used for drug delivery and tissue engineering applications due to their good biocompatibility, biodegradability, and controllable photocurable efficiency. Phosphate buffer solution (PBS) is the most widely used reaction system for GelMA sy …
Gelatin methacryloyl (GelMA) is a photo-crosslinkable polymer with excellent biocompatibility, biodegradability, and moldability. It can be used to fabricate various forms of hydrogels for tissue engineering, drug delivery, biosensing, and organ-on-a-chip.
2.1. GelMA Synthesis and Hydrogel Preparation . GelMA of different degrees of functionalization (DoF) (50%, 70%, and 95%) was synthesized and analyzed as described earlier [].GelMA solutions were prepared at a concentration of 5% (w/v) by weighing an appropriate amount of GelMA and dissolving it in phosphate-buffered saline (PBS, pH 7.4), in PBS with the addition of 2.5%, 50% hPL (% v/v), or ...