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HATU was first reported by Louis A. Carpino in 1993 as an efficient means of preparing active esters derived from 1-hydroxy-7-azabenzotriazole (HOAt). [3] HATU is commonly prepared from HOAt and TCFH under basic conditions [4] and can exist as either the uronium salt (O-form) or the less reactive iminium salt (N-form).HATU was initially reported as the O-form using the original preparation ...
Aldrich-445460; HATU 0.97; CAS No.: 148893-10-1; Synonyms: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; N ...
O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | C10H15F6N6OP | CID 6409673 - structure, chemical names, physical and chemical properties ...
HATU - chemical structure, common uses, and safety. Structure: CAS Number: 148893-10-1 Molecular Weight: 380.23 g/mol Appearance: White crystalline solid Melting Point: 183-185 C
Reagents for Condensation Reactions (HATU) (HPMC encapsulated) Product # R0295: CAS RN: 148893-10-1: Purity / Analysis Method: View Full Details. Product Categories. Chemistry. Chemical Biology. Peptide Chemistry. Peptide Coupling Agents. Phosphonium Salts, Uronium Salts, Formamidinium Salts [Peptide Chemistry]
HATU is a condensation reagent that activates carboxyl groups and promotes amide bond formation. It is widely used in organic and peptide synthesis, and has low toxicity and mutagenicity.
History. HATU was first reported by Louis A. Carpino in 1993 as an efficient means of preparing active esters derived from 1-hydroxy-7-azabenzotriazole (HOAt). [3] HATU is commonly prepared from HOAt and TCFH under basic conditions [4] and can exist as either the uronium salt (O-form) or the less reactive iminium salt (N-form).HATU was initially reported as the O-form using the original ...
HATU is a golden-standard reagent for generating an active ester from carboxylic acid and forming an amide bond without heating. It is a stable white powder, soluble in polar aprotic solvents, and performs well in the case of hindered substrates.
HATU is a coupling reagent commonly used in peptide synthesis. It is an acronym that stands for 2-(1H-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, and it facilitates the formation of amide bonds between amino acids during the synthesis of peptides and proteins.
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds. Generally DMF is used as solvent, although other polar organic solvents can also be used.