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Heparan sulfate is a member of the glycosaminoglycan (GAG) family of carbohydrates and is very closely related in structure to heparin. Both consist of a variably sulfated repeating disaccharide unit. The main disaccharide units that occur in heparan sulfate and heparin are shown below. The most common disaccharide unit within heparan sulfate is composed of a glucuronic acid (GlcA) linked to N ...
The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their effects extracellularly ...
The importance of heparan sulphate, which is ubiquitously expressed as a proteoglycan, in leukocyte extravasation is often overlooked. Owing to the remarkable structural diversity of heparan ...
Heparan sulfate is a ubiquitous component found on the surface of nearly all cell types and throughout the extracellular matrix in animal tissues. Its diverse structure allows it to participate in a wide range of biological interactions. Heparin, in contrast, is primarily known as a pharmaceutical anticoagulant drug.
Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and in the extracellular matrix of most animal tissues, having essential functions in development and homeostasis, as well as playing various roles in disease processes.
Heparan Sulfate/Heparin Biosynthesis Structure Function Group Heparan sulfates (HS) are highly sulfated polysaccharides found on the surface of mammalian cells attached to core proteins and can also be secreted into the extracellular matrix.
The meaning of HEPARAN SULFATE is a sulfated glycosaminoglycan that accumulates in bodily tissues in abnormal amounts in some mucopolysaccharidoses —called also heparitin sulfate.
Heparan sulfates (HSs) are linear polysaccharide chains attached to select surface proteins (HS proteoglycans [HSPGs]) that are present in all eukaryotic cells. They are part of a family of molecules known as glycosaminoglycans, which also include chondroitin/dermatan sulfate, keratan sulfate, and hyaluronic acid. HS chains are synthesized as repeating disaccharide units of hexuronic acid ...
Heparan sulfate is a linear polysaccharide composed of repeating disaccharide subunits of uronic acid and glucosamine. It is conjugated to a core protein and can be expressed on cell surfaces as a heparan sulfate proteoglycan. Heparan sulfate plays a critical role in various disease states due to its dynamic structural complexity and ability to undergo modifications. AI generated definition ...
Heparan sulfate (HS) is synthesized in majority of cells in the human body and is typically released as an extension of polysaccharide chains, which then covalently bind to the protein core of proteoglycans to form heparan sulfate proteoglycans (HSPG). Research has shown that HS plays a crucial role in various cellular pathways of bone repair and regeneration and this review aims to summarize ...