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Interleukin 15 (IL-15) is a cytokine that regulates immune responses and inflammation. It is produced by various cells and binds to receptors on T cells, natural killer cells, and other immune cells.
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair …
IL-15 is a protein that stimulates tumor-fighting immune cells and has been tested in clinical trials for melanoma and renal cell cancer. Learn how NIH researchers co-discovered IL-15 and developed it as a potential therapy for cancer and autoimmune disorders.
The discovery of IL-15 in 1994 was the first step in the development of a promising alternative to IL-2 [4-6, 11-13]. Like IL-2, IL-15 is a powerful lymphocyte growth factor for CD8 + T cells and NK cells. Both IL-2 and IL-15 induce similar intracellular signaling through the shared IL-2 receptor (R) βγ subunits.
IL-15 plays a crucial role in enhancing the survival, proliferation, and activation of various immune cells, particularly memory CD8+ T cells and natural killer (NK) cells. IL-15 binds to a receptor complex on these cells, initiating intricate signaling pathways that bolster immune responses against infections and malignancies.
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems.
IL-15 treatment resulted in a dose-dependent (50-5,000 pg ml -1) increase in CREM expression (Fig. 1h) that was more substantial than with equivalent doses of IL-2 (Extended Data Fig. 2d) and ...
Interleukin 15 (IL-15) is an immunomodulating cytokine that is structurally and functionally related to IL-2. IL-15 promotes the ontogeny, activation, and survival of NK cells, NKT cells, T cells, and B cells. IL-15 also plays controversial roles in the development and progression of various hematological malignancies.
Abstract. Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we …