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Interleukin 15 (IL-15) is a cytokine that regulates innate and adaptive immunity. Learn about its structure, expression, function, receptor, and role in various diseases and conditions.
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair …
The importance of IL-15 in the elimination of syngeneic MC38 colon-carcinoma cells has been examined using Il15-transgenic mice, which produce large quantities of IL-15 (Ref. 41).
The IL-15 receptor is composed of the IL-2Rβ and γc subunits, along with a unique ligand-specific subunit, IL-15Rα, which bears homology to IL-2Rα.These receptor proteins feature protein-binding motifs known as "sushi domains." In both humans and mice, these receptors and their corresponding ligands are physically linked in the genome.
IL-15, a 14-15-kD 4-α helix bundle family cytokine member, belongs to the same family as IL-2 and was discovered in 1994 by two laboratories (6-8). It is a pleiotropic cytokine with a major role in the ontogeny, activation, and survival of CD8+ T cells, NKT cells, γδT cells, and NK cells (9, 10).
IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Graft-Versus-Host Disease and Severe Combined Immunodeficiency, X-Linked.Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. IL-15 promotes activation of T cells, neutrophils and macrophages, and is critical to dendritic cell function in several model systems.
The IL-15 gene spans 34 kb or more, mapping to human chromosome 4q31 and the central region of mouse chromosome 8.10,11 The genomic structure of human IL-15 contains 9 exons (7 coding exons), with a similar intron/exon structure and estimated size between the murine and human IL-15 genes.10,11 More recently, an alternative exon has been described in human12-14 and murine15,16 IL-15, consisting ...
Cell-based cancer immunotherapy, such as chimeric antigen receptor (CAR) engineered T and natural killer (NK) cell therapies, has become a revolutionary new pillar in cancer treatment. Interleukin 15 (IL-15), a potent immunostimulatory cytokine that potentiates T and NK cell immune responses, has demonstrated the reliability and potency to potentially improve the therapeutic efficacy of ...
Interleukin (IL)-15 is a γc cytokine, produced by various cells in the body [1].It is a multifunctional cytokine that targets many cell types and connects the innate with the adaptive immune system [1].It is a member of the 4-α-helical bundle family of cytokines, with 14-15 kDa molecular weight and 114 amino acids [2].Its widespread expression and the ability to influence both immune and ...