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Interleukin 15 (IL-15) is a cytokine that regulates immune responses and inflammation. It is produced by various cells and binds to receptors on T cells, natural killer cells, and other immune cells.
Abstract. Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.
This editorial reviews the history and development of IL-15, a lymphocyte growth factor, as a potential immunotherapy for cancer. It focuses on the first IL-15 superagonist, N-803, that received FDA approval for bladder cancer in 2024.
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair …
IL-15, a 14-15-kD 4-α helix bundle family cytokine member, belongs to the same family as IL-2 and was discovered in 1994 by two laboratories (6-8). It is a pleiotropic cytokine with a major role in the ontogeny, activation, and survival of CD8+ T cells, NKT cells, γδT cells, and NK cells (9, 10).
IL-15: Herald to a New Era of Prevention and Treatment . IL-15 as a Vaccine Adjuvant. In the quest for effective vaccines against diverse pathogens, IL-15 emerges as a conductor orchestrating robust immune responses. Its prowess as a vaccine adjuvant shines in studies against HIV, influenza, and tuberculosis, inducing enduring cellular and ...
Interleukin (IL)-15 is a γc cytokine, produced by various cells in the body [1].It is a multifunctional cytokine that targets many cell types and connects the innate with the adaptive immune system [1].It is a member of the 4-α-helical bundle family of cytokines, with 14-15 kDa molecular weight and 114 amino acids [2].Its widespread expression and the ability to influence both immune and ...
IL-15 plays a crucial role in enhancing the survival, proliferation, and activation of various immune cells, particularly memory CD8+ T cells and natural killer (NK) cells. IL-15 binds to a receptor complex on these cells, initiating intricate signaling pathways that bolster immune responses against infections and malignancies.
IL-15 is a protein that stimulates tumor-fighting immune cells and has been tested in clinical trials for melanoma and renal cell cancer. Learn how NIH researchers co-discovered IL-15 and developed it as a potential therapy for cancer and autoimmune disorders.
A review article that summarizes the molecular and cellular biology of IL-15, a cytokine with similar functions to IL-2 but distinct receptor specificity and expression patterns. It also discusses the roles of IL-15 in immunity, autoimmunity, and malignancy, and its potential clinical applications.