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Interleukin 23 (IL-23) is a cytokine that regulates inflammation, immunity and cancer. It is a heterodimer composed of IL-12B and IL-23A subunits, and acts on Th17 cells, innate lymphoid cells, natural killer cells and B cells.
IL-23 is a chemical that helps maintain immune cells called Th17 cells, which normally protect against infections. In autoimmune disease, IL-23 becomes overactive and causes Th17 cells to produce excessive amounts of inflammatory substances. IL-23 inhibitors attach to IL-23 and prevent it from activating Th17 cells, thereby reducing inflammation.
Interleukin-23 (IL-23) is a member of the IL-12 family of cytokines with pro-inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 (Th17) cells indicates the responsibility for many of the inflammatory autoimmune ...
IL-23 controls immune cells. Learn how IL-23 is the target of potential Johnson & Johnson medications that could treat psoriasis, IBD and rheumatoid arthritis.
Interleukin (IL) 23, a member of the IL12 family of cytokines, maintains intestinal homeostasis, but is also implicated in the pathogenesis of inflammatory bowel diseases (IBDs). IL23 is a heterodimer composed of disulfide-linked p19 and p40 subunits. Humanized monoclonal antibodies selectively targeting the p19 subunit of IL23 are poised to become prominent drugs in IBDs. In this review, we ...
Interleukin-23 is a key cytokine that regulates specific immune responses. This article explains how its activity contributes to both bodily defense and disease.
IL-23 inhibitors are a type of biologic that can treat moderate to severe psoriasis. Learn more about these medications, including how they work, the possible side effects, and more.
This review provides a comprehensive evaluation of IL-23 in the onset and progression of inflammatory diseases. By evaluating its immunological functions, role in disease pathogenesis, and therapeutic potential, this paper highlights IL-23 as both a biomarker and a target for therapeutic intervention in many chronic inflammatory diseases.
Explore how IL-23 inhibitors are shaping modern immunotherapy, their mechanisms, clinical applications, and what they mean for targeted immune modulation.
IL-23 is a cytokine that regulates Th17 and type-17 cells and drives immune-mediated inflammatory diseases, such as psoriasis, psoriatic arthritis, and inflammatory bowel disease. This review summarizes IL-23 biology, signaling, and inhibition in IMIDs and proposes future studies to advance IL-23 science and therapy.