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LAMP1 is a gene that encodes a glycoprotein involved in lysosomal membrane integrity, organelle transport and viral entry. It is also a marker of lymphocyte degranulation and tumor cell differentiation.
LAMP1 (lysosomal associated membrane protein 1) and LAMP2 are distributed among autophagic and endolysosomal organelles. Despite widespread distribution, LAMP1 is routinely used as a lysosome marker and LAMP1-positive organelles are often referred to as lysosomal compartments.
LAMP1 is a protein coding gene that encodes a lysosomal membrane glycoprotein involved in lysosome biogenesis, pH regulation, autophagy and cholesterol homeostasis. It also acts as a receptor for some viruses and a ligand for selectins.
Gene target information for LAMP1 - lysosomal associated membrane protein 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
However, Lamp1 deficiency results in an increase in the number of acidic organelles in flies. Furthermore, we find that Lamp1 mutant larvae have defects in lipid metabolism as they show elevated levels of sterols and diacylglycerols (DAGs).
Zhang et al. utilized a multidisciplinary approach to unravel a key functional role of LAMP proteins in regulating lysosomal pH homeostasis. They demonstrated that LAMP-1 and -2 directly interact with TMEM175 and inhibit its channel activity. This LAMP inhibition facilitates the lysosomal acidification to a lower pH, which is optimal for the lysosomal hydrolytic activity.
LAMP1 is a protein-coding gene that encodes lysosomal-associated membrane protein 1, a glycoprotein involved in lysosome biogenesis, autophagy, and NK-cell cytotoxicity. Learn about its structure, function, associated diseases, and potential biomarker and drug target applications.
Lysosome-associated membrane protein 1 (LAMP-1) inhibitors are emerging as a promising field in medical research with potential applications across various diseases. These inhibitors target LAMP-1, a glycoprotein predominantly located in the lysosomal membrane, which plays a crucial role in cellular homeostasis, autophagy, and immune responses. Understanding the functionality and therapeutic ...
Abstract The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about 50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 or LAMP-2 are viable and fertile. However, mice deficient in both LAMP-1 and LAMP-2 have an embryonic lethal phenotype. These results show that these two major lysosomal membrane proteins share common ...
LAMP1 has only one transcript, whereas LAMP2 has three different splicing isoforms: LAMP2A, LAMP2B, and LAMP2C [30,33]. LAMP2 isoforms are expressed in a tissue specific manner and can exert opposing functions [34,35].