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Limbal rings are circular areas of pigment around your iris that can vary in visibility depending on your age, health, and genetics. They are not associated with any health conditions, but some research suggests they can make you more attractive to others.
Limbal stem cells (LSC) represent a quiescent cell population with proliferative capacity residing in the basal epithelial layer of the limbus within a cellular niche. In addition to LSC, this niche consists of various cell populations such as limbal stromal fibroblasts, melanocytes and immune cells as well as a basement membrane, all of which ...
Limbal stem cells are unipotent stem cells that regenerate the corneal epithelium. Learn about their characteristics, medical conditions that affect them, and surgical procedures to restore them.
A limbal ring is a dark ring around the iris of the eye, where the sclera meets the cornea. It may indicate health, youth, and attractiveness, and is related to corneal stem cells.
Limbal stem cells are harvested with a carrier which may be conjunctiva (conjunctival-limbal grafts) or cornea (Keratolimbal grafts)90 A variety of methods have been employed for preparing transplant sheets, e.g. a sheet of corneal epithelial cells alone, a sheet of corneal epithelial cells cultured on a polymer substrate, collagen or fibrin,91 ...
The importance of these stem cells is most apparent when their numbers are decreased. With a reduced ability to repopulate the corneal epithelium and an unstable ocular surface, patients with limbal stem cell deficiency (LSCD) can have ocular pain from corneal erosions and decreased vision from stromal scarring or epithelial irregularity.
In order to restore vision, limbal defects must be restored by transplantation of limbal grafts taken from uninjured eyes. In the case of unilateral defects limbal grafts can be taken from the uninjured eye. In bilateral disorders, stem cell allografts dissected from living tissue-matched eyes or non-matched cadaver eyes are performed.
Limbal transplantation is a procedure where limbal tissue is surgically transplanted to an ocular surface with LSCD. The limbal niche and LESCs are transplanted simultaneously. All procedures should be accompanied by anti-inflammatory therapy . This approach is suitable for patients with severe/total LSCD.
Learn about the causes, symptoms, and treatment of limbal stem cell deficiency, a condition that affects the corneal epithelium and vision. Find out how to prevent and diagnose this disease and its complications.
Limbal stem cell deficiency (LSCD) can cause significant corneal vascularization and scarring and often results in serious visual morbidity. An early and accurate diagnosis can help prevent the same with a timely and appropriate intervention. This review aims to provide an understanding of the different diagnostic tools and presents an ...