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MCF-7 is a human breast cancer cell line derived from a 69-year-old woman in 1970. It is widely used for research on breast cancer, hormone receptors, and drug development.
The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene.RefHuguet EL, et al. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue ...
MCF-7 cell line: Origin and general information Before working with the MCF-7 cell line, it is essential to understand, morphology, cell size, and other general characteristics. The name 'MCF-7' stands for Michigan Cancer Foundation - 7. It was established by Dr. Soule at the Michigan Cancer Foundation in Detroit, Michigan.
MCF-7 is a breast cancer cell line derived from a pleural effusion in 1973. It is widely used to study estrogen-dependent, non-invasive, and luminal subtype of breast cancer, as well as photodynamic therapy and drug resistance.
Explore the MCF-7 cell line, a foundational lab model that helps scientists understand hormone-driven breast cancer and develop targeted therapies.
MCF-7 is a widely used cell line for ER-positive breast cancer studies, derived from a metastatic tumor in 1970. It has various phenotypes, sub-lines and molecular subtypes, and can be adapted to different anti-hormone therapies and in vivo models.
We have recently developed a simple, inexpensive method for MCF-7 cell spheroid growth in 96-well low attachment plates. We used this method to test breast cancer drugs for their effect on the MCF-7 spheroid.
The MCF-7 cell line established by Dr. Herbert Soule in 1973 at the Michigan Cancer Foundation (MCF, now named Barbara Ann Karmanos Cancer Institute, KCI) represents the first hormone responsive breast cancer cell line and was derived from the pleural effusion of a woman with metastatic breast cancer.
MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes.
MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27]. MCF-7 cells are useful for in vitro breast studies because they retained several ideal characteristics ...