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p130cas
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This review summarises the structure, function, and regulation of p130Cas, a ubiquitously expressed adaptor protein that interacts with multiple proteins and pathways. It also discusses the roles of p130Cas in cardiovascular development, cancer, and immune system.
BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and v-Crk . p130Cas/BCAR1 belongs to the Cas family of adaptor proteins and can act as a docking protein for several signalling partners. [7] Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways ...
p130Cas/BCAR1 in early embryonic development in mice and flies Although studies of the p130Cas/BCAR1 protein highlight its important roles in cancer and other pathogenic conditions, defining its precise function in early and late tissue and organ development still requires additional investigations.
The involvement of p130Cas in cell motility as a component of the integrin signaling machinery is well established. Here, we discuss recent developments that highlight a fundamental role in cell transformation and microbial pathogenesis and the implications of these developments on p130Cas function under normal and pathological conditions.
p130Cas is a major substrate of the Src tyrosine kinase that functions in integrin signaling to promote cell motility, invasion, proliferation, and survival (reviewed by Defillipi et al. 2006; Tikhmyanova et al. 2010). p130Cas was first recognized in the late 1980s by immunoblot detection with an anti-phosphotyrosine antibody in cells ...
p130Cas/ BCAR1 is an adaptor protein devoid of any enzymatic or transcriptional activity, whose modular structure with various binding motifs, allows the formation of multi-protein signaling complexes. This results in the induction and/or maintenance of signaling pathways with pleiotropic effects on cell motility, cell adhesion, cytoskeleton remodeling, invasion, survival, and proliferation ...
The Cas family scaffolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signaling to promote cell motility, invasion, proliferation, and survival. p130Cas targeting to FAs is essential for its tyrosine phosphorylation and downstream signaling. Altho …
In addition, p130Cas has been shown to be a substrate for several tyrosine kinases (FYN, SRC, ABL) and tyrosine-specific phosphatases (Figure 1). This unique set of molecular partners suggests that the tyrosine phosphorylation of p130Cas plays a pivotal role in regulating cell adhesion and migration.
We investigated the clinical and biological significance of p130cas, an important cell signaling molecule, in ovarian carcinoma. Expression of p130cas in ovarian tumors, as assessed by immunohistochemistry, was associated with tumor characteristics ...
The involvement of p130Cas in cell motility as a component of the integrin signaling machinery is well established. Here, we discuss recent developments that highlight a fundamental role in cell transformation and microbial pathogenesis and the implications of these developments on p130Cas function under normal and pathological conditions. Previous