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pd-l1
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PD-L1 is a transmembrane protein that binds to PD-1 and CD80 to modulate T cell activation and proliferation. It is expressed on various cells and tissues and has been implicated in cancer, autoimmune disease, pregnancy and other conditions.
PD-1/PD-L1 pathway controls the induction and maintenance of immune tolerance within the tumor microenvironment. The activity of PD-1 and its ligands PD-L1 or PD-L2 are responsible for T cell activation, proliferation, and cytotoxic secretion in cancer to degenerating anti-tumor immune responses (Figure 1). Figure 1. Open in a new tab
A PD-L1 test measures the amount of PD-L1 protein on cancer cells to see if immunotherapy can help. Learn about the types of PD-L1 tests, how they are done, and what the results mean.
PD-L1 is a protein that helps cancer cells avoid immune attack. Learn how PD-L1 testing can help you get the best immunotherapy drugs for your lung cancer.
PD-L1 is a protein that helps some cancer cells evade the immune system. Learn how a PD-L1 test can help determine whether a patient may benefit from immune checkpoint inhibitors, a type of cancer drug that blocks the PD-L1/PD-1 interaction.
A type of cancer immunotherapy targets PD-1 or PD-L1 with checkpoint inhibitors designed to block one or the other. Learn more about testing and results.
This review explores the multifaceted roles of PD-L1 in cancer and other diseases, and the potential of PD-L1-targeted therapies. It covers the canonical and non-canonical PD-L1/PD-1 signaling pathways, the mechanisms of PD-L1-mediated cancer cell proliferation, transcriptional regulation, and systemic immunosuppression, and the clinical relevance of PD-L1 as a diagnostic marker and a drug target.
PD-L1 expression is an immune evasion mechanism exploited by various malignancies and is generally associated with poorer prognosis. PD-L1 expression is also suggested as a predictive biomarker of response to anti-PD-1/PD-L1 therapies; however, contradictory evidence exists as to its role across histotypes.
Learn about the checkpoint inhibitor drugs that block PD-1 and PD-L1 proteins to treat various cancers. Find out the history, mechanism, approved drugs, and biomarkers of PD-1/PD-L1 inhibitors.
A protein that acts as a kind of "brake" to keep the body's immune responses under control. PD-L1 may be found on some normal cells and in higher-than-normal amounts on some types of cancer cells.