为您找到"
pf4
"相关结果约100,000,000个
Platelet factor 4 (PF4) is a cytokine and chemokine that promotes blood coagulation and inflammation. It is involved in heparin-induced thrombocytopenia, vaccine-induced immune thrombotic thrombocytopenia, and malaria infection.
Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is heparin-induced thrombocytopenia (HIT), which develops in a ...
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), was the first chemokine identified with multiple biological functions. It was first discovered that PF4 could combine with the anticoagulant heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT) [1, 2].
This article reviews the clinical, serological, and pathogenic features of anti-PF4 antibody disorders, which cause severe thrombosis and thrombocytopenia. It also proposes a new classification of anti-PF4 antibodies into type 1, 2, and 3, and discusses the treatment options for different types of anti-PF4 antibody disorders.
PF4 is a small protein released by blood platelets that improves brain function in older mice. It is also involved in the effects of young blood, klotho, and exercise on the brain. Learn how PF4 works and its potential for anti-aging therapies.
PF4 is a protein coding gene that encodes a chemokine involved in platelet aggregation, hematopoiesis, and inflammation. Learn about its aliases, disorders, pathways, products, and more from GeneCards, a comprehensive database of human genes.
A woman with multiple episodes of pulmonary embolism and venous thrombosis who had platelet-activating antibodies to PF4 was treated with high-dose IVIG, plasma exchange, and daily ibrutinib after ...
Platelet factor 4 (PF4), also referred to as CXCL4, is a significant component of the C-X-C chemokine family, predominantly localized within the alpha granules of platelets. It is recognized for its anti-heparin and anti-angiogenic properties. ...
Platelet Factor 4 (PF4) is a chemokine stored in platelets that activates coagulation and inhibits angiogenesis. Learn about its structure, function, and role in heparin-induced thrombocytopenia and gene therapy.
Young PF4-deficient HSCs also showed reduced polar distribution of Cdc42 and alpha-tubulin, identical to the frequencies seen in old mice. These results suggest that PF4 levels might be critical in preventing the aging of the hematopoietic system. Next, we tested the effect of short-term PF4 treatment (1 μg/mL) on old HSCs.