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Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases.
poly-A tail is a string of adenine nucleotides added to mRNA during RNA processing. It increases the stability and export of mRNA and allows translation into protein.
Note that the process of Poly A tailing also occurs in the microRNAs as well. In the prokaryotes, the poly-A tailing leads to the degradation of mRNA to regulate the gene expression. The normal range of the poly-A tail adding; is 100 to 150 adenosine but! Interestingly, studies reveal that different lengthed genes have a variable poly-A tail.
Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site. Genes Dev 9: 3008-3025 [Google Scholar] Ashe MP, Pearson LH, Proudfoot NJ 1997. The HIV-1 5′ LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site.
Abstract. Poly(A) tails, present on almost every eukaryotic mRNA, were discovered over 50 years ago. Early experiments led to the hypothesis that poly(A) tails and the cytoplasmic poly(A)-binding protein promote translation and prevent mRNA degradation, but the details remained unclear.
The poly(A) tail also has a role facilitating transport of the mature mRNA out of the nucleus (nucleocytoplasmic transport), and although the details are unclear, it is known that the adenosine analog 3′-deoxyadenosine (cordycepin) inhibits polyadenylation of nuclear RNA and curtails the appearance of these transcribed, nonadenylated ...
We explain how poly(A) tail dynamics help regulate cognate RNA metabolism in a context-dependent manner, such as during oocyte maturation. Finally, we describe specific mRNAs in metazoans that bear stem-loops instead of poly(A) tails. We conclude with how recent discoveries about poly(A) tail can be applied to mRNA technology.
In eukaryotes, poly(A) tails are present on almost every mRNA. Early experiments led to the hypothesis that poly(A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) promote ...
Polyadenylation is a crucial post-transcriptional modification in eukaryotic cells where a sequence of adenine nucleotides (the poly(A) tail) is added to the 3' end of messenger RNA. 1. Initial Transcription
The poly(A) tails present at the 3′ end of almost all eukaryotic mRNAs have two major functions. The first function is in the control of mRNA decay; degradation of the poly(A) tail by a 3′ exonuclease (deadenylation) is the first step in both of the two main pathways of mRNA decay, and the completion of deadenylation triggers the second step, either cap hydrolysis or further 3′-5 ...