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RBPJ [8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.
RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a Protein Coding gene. Diseases associated with RBPJ include Adams-Oliver Syndrome 3 and Adams-Oliver Syndrome. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Autodegradation of the E3 ubiquitin ligase COP1.
The RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Learn about this gene and related health conditions.
RBPJ is a transcription factor and a downstream effector of the Notch signaling pathway. It is involved in various biological processes, such as cardiac development, arterial identity, mitochondrial function, and cancer progression.
RBPJ is the major transcriptional effector of Notch signaling, which regulates cell-fate choices. The authors show that RBPJ remains associated with chromatin throughout mitosis, and suggest that it can mark genes for efficient transcriptional activation or repression upon mitotic exit.
Here, we report that postnatal inactivation of the Rbpj gene, encoding the transcription factor RBPJ, leads to alteration of cell identity markers in brain pericytes, increases local TGFβ ...
Signal transduction pathways often involve transcription factors that promote activation of defined target gene sets. The transcription factor RBPJ is the central player in Notch signaling and either forms an activator complex with the Notch ...
RBPJ expression in glioblastoma stem‐like cells (GSCs) and the effect of RBPJ knockdown on the proliferation and self‐renewal of GSCs. A, RBPJ expression in GSC lines, as assessed by western blotting.
Gene target information for RBPJ - recombination signal binding protein for immunoglobulin kappa J region (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
Transcriptional regulator Rbpj is involved in T-helper subset differentiation. Here the authors show that expression of Rbpj in regulatory T cells is required to both regulate TH2 responses and ...