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Reelin is a large glycoprotein that regulates neuronal migration and positioning in the developing and adult brain. It is also involved in synaptic plasticity, neurogenesis, and some brain diseases.
Lissencephaly with cerebellar hypoplasia. Several variants in the RELN gene have been found to cause lissencephaly with cerebellar hypoplasia (LCH). This condition affects brain development, resulting in the brain having a smooth appearance (lissencephaly) instead of its normal folds and grooves.
RELN (Reelin) is a Protein Coding gene. Diseases associated with RELN include Epilepsy, Familial Temporal Lobe, 7 and Lissencephaly 2.Among its related pathways are Nervous system development and PI3K-Akt signaling pathway.Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and very-low-density lipoprotein particle receptor binding.
Reelin has been primarily identified as a regulator of neuronal migration and function, but its non-neuronal functions remain underestimated. Alexander et al. review Reelin signaling in the development and physiology of several organs. They cover its pro-inflammatory and pro-thrombotic roles together with its therapeutic potential for autoinflammatory and autoimmune diseases.
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing ...
Introduction. Disruptions of the autosomal recessive Reelin gene were identified two decades ago to be responsible for the reeler phenotype in mice strains originated from Edinburgh and Orleans (D'Arcangelo et al., 1995; Hirotsune et al., 1995).The Edinburgh homozygous mutant reeler mouse displays a complete loss of transcription of the gene (D'Arcangelo et al., 1995) whereas the Orleans ...
A key protein that helps assemble the brain early in life also appears to protect the organ from Alzheimer's and other diseases of aging. A trio of studies published in the past year all suggest that the protein Reelin helps maintain thinking and memory in ailing brains, though precisely how it does this remains uncertain.
At embryonic day (E) 13.5 (the preplate stage) pioneer neurons migrate — probably by somal translocation 76 — and form a loose horizontal network. Some are reelin (Reln)-positive (red) and ...
During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has bee …
A protein called Reelin may help protect brains against aging and Alzheimer's : Shots - Health News Early in life, the protein Reelin helps assemble the brain. Later on, it appears to protect ...