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A single-domain antibody (sdAb) is a small protein that can bind to a specific antigen. Learn about its properties, production methods, and applications in medicine and research.
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sdAb-DB is a repository and database of natural and synthetic camelid single domain antibody sequences. Users can search for sdAbs by name, target, source, and other features, and access amino acid sequences, uses, and citations.
The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range of applications, including as a rational design tool, and are therefore of great interest for synthetic ...
The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies, sdAb is a unique antibody fragment consisting of a heavy-chain variable ...
Single domain antibody (sdAb) is composed of a variable domain of heavy chain and devoid of the light chain completely. 3 Despite its small size (about 15 kDa), sdAb is capable of binding an antigen with high specificity and affinity. The single domain nature of sdAb allows it to be engineered readily into various recombinant antibodies. 1
Single domain antibodies (sdAbs), also known as nanobodies, are antibody fragments derived from heavy-chain-only antibodies found in camelids and cartilaginous fish. Their small size and unique structure make them valuable for research, diagnostics, and therapeutic applications. Advancements in sdAb engineering have improved stability, binding affinity, and production efficiency, making them ...
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic applications. Therefore, engineering strategies ...
The Single Domain Antibody Database, or sdAb-DB, (www.sdab-db.ca) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range of applications, including as a rational design tool, and are therefore of great interest for synthetic ...
We converted a potent antagonistic sdAb JN241 to an agonistic sdAb JN241-9 to human APJ by structure-guided rational design.