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SRCR is a protein domain found in eukaryotes that mediates non-opsonic phagocytosis and immune response. Learn about its function, structure, examples and references from Wikipedia.
1. Title. These rules may be known and cited as Nevada Rules for Sealing and Redacting Court Records, or abbreviated SRCR.
The Scavenger Receptor Cysteine-Rich (SRCR) domain is an ancient and highly conserved protein module of ~100-110 amino acids, which defines a superfamily (SRCR-SF) of either soluble or membrane-bound receptors expressed by hematopoietic and nonhematopoietic cells, at either embryonic or adult stages.
This receptor is classified as the Class I scavenger receptor because of the presence of type B scavenger receptor cysteine-rich (SRCR) domain, which are encoded by a single exon and containing eight cysteine residues. SR-I1 is a 130 kDa transmembrane Type 1 membrane glycoprotein that is primarily expressed in monocytes and macrophages.
Of the SRCR-containing receptors, SCARA5 and SR-A have been shown to be more closely related to each other than to MARCO. Analyses have shown that the SRCR-containing cA-SRs diverged from SCARA3 and SCARA4, perhaps as early as within the genomes of teleost fish (20). However, the domain structure of the ancestral receptor remains unresolved.
The scavenger receptor cysteine-rich (SRCR) superfamily comprises a highly conserved group of extracellular soluble and membrane-attached glycoproteins that function as pattern recognition receptors against a diverse range of pathogenic determinants. While considerable attention has been devoted to their roles in microbial recognition, this perspective aims to emphasize the significant, yet ...
The scavenger receptor cysteine-rich (SRCR) superfamily of soluble or membrane-bound protein receptors is characterized by the presence of one or several repeats of an ancient and highly conserved protein module, the SRCR domain. This superfamily (SRCR-SF) has been in constant and progressive expans …
The scavenger receptor cysteine-rich (SRCR) domain is an ancient and highly conserved domain of ~110 residues that was first recognized during the analysis of type I macrophage scavenger receptor ...
The structure of these receptors comprises an amino-terminal cytoplasmic tail, a transmembrane domain, a spacer region, an α-helical coiled-coil domain, a collagenous domain, and an ancient conserved carboxy-terminal scavenger receptor cysteine-rich (SRCR) domain (Figure 1).
The scavenger receptor cysteine-rich (SRCR) superfamily of soluble or membrane-bound protein receptors is characterized by the presence of one or several repeats of an ancient and highly conserved protein module, the SRCR domain. This superfamily (SRCR-SF) has been in constant and progressive expansion, now up to more than 30 members. The study of these members is attracting growing interest ...