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TEAD1 is a protein that regulates the expression of genes involved in muscle differentiation, proliferation and apoptosis. It binds to DNA through a TEA domain and to cofactors through a YAP1 binding domain.
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Transcriptional enhanced associate domain (TEAD) transcription factors play important roles during development, cell proliferation, regeneration, and tissue homeostasis. TEAD integrates with and coordinates various signal transduction pathways ...
TEADs are transcription factors that regulate progenitor proliferation, stem cell identity and lineage specification in various tissues. They interact with co-factors such as YAP, TAZ and VGLLs, and are involved in Hippo signalling and other pathways.
TEAD (TEA/ATTS domain) proteins are evolutionarily conserved transcription factors [1,2]. TEAD1-4 in mammals and Scalloped in Drosophila have been the most studied. TEADs were initially identified as factors occupying the enhancer region of the SV40 virus [3] as well as promoters and enhancers of muscle-specific genes [4]. The TEAD-binding motif has also been referred to as the muscle ...
We also found that depletion of TEAD proteins makes cells more susceptible to DNA damage by various agents and that depletion of TEADs promotes genomic instability. Additionally, depleting TEADs dampens the efficiency of DNA double-stranded break repair in reporter assays.
TEADs are transcription factors and core components of the Hippo pathway, which is involved in various human diseases. This review summarizes the recent progress, challenges, and opportunities in modulating TEAD activities with small molecules.
Learn how TEAD factors regulate gene expression, cell adhesion, and extracellular matrix in various tissues and diseases. Explore their structural features, signaling interactions, and methods to investigate them.
The TEAD family of transcription factors is necessary for developmental processes. The family members contain a TEA domain for the binding with DNA elements and a transactivation domain for the interaction with transcription coactivators. TEAD ...