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Transcription factor II D (TFIID) is a complex of proteins that binds to the core promoter of eukaryotic genes and recruits RNA polymerase II for transcription. Learn about its functions, structure, subunits, and references.
TFIID is a large multiprotein complex that binds to core promoter DNA and recruits RNA polymerase II for transcription initiation. This review summarizes the recent cryo-EM studies that reveal the structure and dynamics of human and yeast TFIID, and their implications for transcription regulation.
A sub-nanometre resolution cryo-EM structure of human TFIID bound to TFIIA and core promoter DNA and a model of the TFIID-based pre-initiation complex.
A cryo-EM structural analysis elucidates the molecular architecture and mechanism of transcription initiation.
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) ...
Transcription factor IID (TFIID), a large multiprotein assembly formed by the TATA box binding protein (TBP) and 14 additional TBP-associated protein factors (TAFs), is a critical constituent of the machinery responsible for the exquisitely regulated transcription of eukaryotic protein-encoding genes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preini ...
Binding of TFIID to the TATA box is the first transcription step of the pre-initiation complex, and plays a role in activating eukaryotic genes transcribed by RNA polymerase II.
TFIID is the first general transcription factor to bind gene promoters prior to gene transcription by RNA polymerase II, triggering pre-initiation complex formation and functioning as a coactivator.
TFIID is a large multiprotein assembly that serves as a general transcription factor for transcription initiation by eukaryotic RNA polymerase II (Pol II). TFIID is involved in the recognition of the core promoter sequences and neighboring chromatin marks, and can interact with gene-specific activators and repressors.
Basal transcription factor TFIID connects transcription activation to the assembly of the RNA polymerase II preinitiation complex at the core promoter of genes. The mechanistic understanding of TFIID function and dynamics has been limited by the lack of high-resolution structures of the holo-TFIID complex. Recent cryo-electron microscopy studies of yeast and human TFIID complexes provide ...