为您找到"
traf1
"相关结果约100,000,000个
TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling. [7] This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases. [8] Interactions. TRAF1 has been shown to interact with:
TRAF1 and TRAF 2 proteins in TNFRI signaling. (A) Schematic of TRAF1 and 2 structure, indicating the site of phosphorylation of human TRAF1 by PKN1.(B) Role of TRAF1 and 2 in activation of NF-κB by TNFRI. TNFRI recruits TNFR associated death domain, TRADD, which in turn recruits TRAF2. TRAF1 associates with the TRADD/TRAF2 complex and the TRAF complex recruits the cellular inhibitors of ...
TRAF1 is a protein coding gene that mediates the signal transduction from TNF receptors and regulates cell survival and apoptosis. Learn about its aliases, disorders, pathways, products, expression, localization, and more from GeneCards database.
TRAF1 plays a key role in pro-survival signaling downstream of TNFR superfamily members such as TNFR2, LMP1, 4-1BB, and CD40. Recent studies have uncovere … Tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) is a signaling adaptor first identified as part of the TNFR2 signaling complex.
TRAF1 is a crucial adaptor molecule that plays a role in the assembly of receptor-associated signaling complexes. Compared with other members of TRAF family, TRAF1 mRNA expression is only detectable in a few tissues, including lung, spleen, and testis . These findings suggested that TRAF1 is unique and may function in specific organs.
TRAF1 is a signaling adaptor known for its role in tumor necrosis factor receptor-induced cell survival. Here we show that monocytes from healthy human subjects with a rheumatoid arthritis ...
TRAF1 is an intracellular signalling molecule that has diverse biological functions. In this study, the authors show that TRAF1 is expressed in mice soon after they have suffered a stroke and that ...
TRAF1 single-nucleotide polymorphisms are associated with rheumatoid arthritis in both Asians and Caucasians and are possibly correlated with causative variations. Data show that TRAF1 is an important molecule mediating both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents the lymphoma cells from spontaneous and ...
Conversely, TRAF1 −/− mice have reduced inflammatory stroke lesions and ameliorated behavioral and neurological dysfunction associated with reduced neuronal apoptosis . Mechanistically, TRAF1 directly interacts with ASK1 to induce the MKK4/7-JNK1 pro-apoptotic pathway while inhibiting the Akt-mTOR-CREB pro-survival pathway in neurons .
TRAF1 −/− T cells exhibit hyperproliferation and increased production of Th2 cytokines (IL-4, IL-5 and IL-13) in response to TCR signaling, but defective 4-1BB-mediated survival responses in effector and memory CD8 T cells [77-79, 171, 266]. Hyperproliferation of TRAF1 −/− T cells is due to constitutive activation of the NF-κB2 pathway .