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TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling. [7] This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases. [8] Interactions. TRAF1 has been shown to interact with:
TRAF1 is a protein coding gene that mediates the signal transduction from TNF receptors and regulates cell survival and apoptosis. Learn about its aliases, disorders, pathways, products, expression, localization, and more.
TRAF1 and TRAF 2 proteins in TNFRI signaling. (A) Schematic of TRAF1 and 2 structure, indicating the site of phosphorylation of human TRAF1 by PKN1.(B) Role of TRAF1 and 2 in activation of NF-κB by TNFRI. TNFRI recruits TNFR associated death domain, TRADD, which in turn recruits TRAF2. TRAF1 associates with the TRADD/TRAF2 complex and the TRAF complex recruits the cellular inhibitors of ...
TRAF1 single-nucleotide polymorphisms are associated with rheumatoid arthritis in both Asians and Caucasians and are possibly correlated with causative variations. Data show that TRAF1 is an important molecule mediating both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents the lymphoma cells from spontaneous and ...
TRAF1 plays a key role in pro-survival signaling downstream of TNFR superfamily members such as TNFR2, LMP1, 4-1BB, and CD40. Recent studies have uncovere … Tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) is a signaling adaptor first identified as part of the TNFR2 signaling complex.
TRAF1 is a signaling adaptor known for its role in tumor necrosis factor receptor-induced cell survival. Here we show that monocytes from healthy human subjects with a rheumatoid arthritis ...
Conversely, TRAF1 −/− mice have reduced inflammatory stroke lesions and ameliorated behavioral and neurological dysfunction associated with reduced neuronal apoptosis . Mechanistically, TRAF1 directly interacts with ASK1 to induce the MKK4/7-JNK1 pro-apoptotic pathway while inhibiting the Akt-mTOR-CREB pro-survival pathway in neurons .
TNF receptor-associated factor 1 (TRAF1) is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in activated lymphocytes. To elucidate the function of TRAF1, we generated TRAF1-deficient mice. TRAF1−/− mice are viable and have normal lymphocyte development. TRAF1−/− T cells exhibit stronger than wild-type (WT) T cell proliferation to anti-CD3 mAb ...
TRAF1 is a unique family of TRAF lacking the N-terminal RING finger domain. TRAF1 is an important scaffold protein that participates in TNFR2 signaling in T cells as a negative or positive regulator via direct interaction with TRAF2, which has recently been identified as a pro-apoptotic regulator in neuronal cell death.
TRAF1 is an atypical member of the TRAF family, as it lacks a RING domain and has a single zinc finger . Although many early studies of TRAF1 were conducted in epithelial or fibroblast cell lines, its physiologic expression is restricted to spleen, lung, and testis, particularly to immune cells (reviewed in ). The first report to focus upon ...